Search for dissertations about: "LTNP"

Showing result 1 - 5 of 6 swedish dissertations containing the word LTNP.

  2. 1. Viral parameters influencing clinical long-term non progression in HIV-1 infected subjects

    Author : Ubaldo Visco Comandini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : LTNP; HIV-1 DNA; HIV-1 RNA; quantification; spontaneous decrease; genetic heterogeneity; nef; LTR; CCR5 deletion;

    Abstract : A very small portion of the HIV-1 infected population is constituted by individuals, called long- term non progressors (LTNP), in whom after even a decade or more, no visible deterioration of the immune system is recognized and the infection remains therefore asymptomatic. The reasons for such "natural" prolonged well-being can be attributed to both the virus and the infected host and their understanding is likely to give important information for the development of an effective HIV- vaccine and for immune reconstitution therapy. READ MORE

  4. 2. Slow progression in HIV-1 infection : clinical, virological and immunological study

    Author : Christina Broström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; PHI; prognosis; slow progression; LTNP; longitudinal; specific pattern; HIV-1 RNA; HIV-1 DNA; spontaneous decrease;

    Abstract : The aim of the present thesis was to study factors that could possibly influence the course of HIV-1 infection with special emphasis on slow progression of the disease. Clinical, virological and immunological parameters were evaluated. One important clinical factor for the outcome of HIV-1 infection was identified. READ MORE

  5. 3. Virus tropism and neutralization response in SIV infection

    Author : Anna Laurén; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; Medicin människa och djur ; Medicine human and vertebrates ; HIV; SIV; mode of CCR5 use; CD4-independence; macrophage tropism; coreceptor use; neutralization; evolution; pathogenesis;

    Abstract : Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. READ MORE

  6. 4. Regulation and role of IL-7 production in HIV-1 infection

    Author : Hong Thang Pham; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The concentration of interleukin-7 (IL-7) in human serum is elevated in various clinical conditions associated with lymphopenia, including HIV-1 infection. IL-7 is an essential factor for T cell differentiation and survival, and it was suggested that high serum IL-7 concentration may represent a homeostatic response to T cell depletion, which may promote T cell regeneration. READ MORE

  7. 5. Leukemia inhibitor factor (LIF) and gp130 in early defence against HIV-1 infection

    Author : Annelie Tjernlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : LIF; HIV-1; lymphoid tissue; cytokine; innate immune response; Jak Stat signalling pathway; cMAGI cells; siRNA;

    Abstract : Leukemia inhibitor factor (LIF) is a polyfunctional cytokine that belongs to the IL-6 family which mainly signals through the Jak/Stat pathway via the gp130/LIFR-α heterodimer. The focus of my research has been to investigate and understand if and how LIF exerts HIV1 suppressing activity. READ MORE