Search for dissertations about: "Large B-Cell"

Showing result 1 - 5 of 107 swedish dissertations containing the words Large B-Cell.

  1. 1. Protein kinases and phosphatases in B-cell lymphoma

    University dissertation from Inst för Laboratoriemedicin, Avd för tumörbiologi, Malmö Universitetssjukhus, Lunds Universitet

    Author : Marie Fridberg; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HePTP; PTEN; PKC-beta 2; B-cell; lymphoma; kinases; ZAP70; phosphatase; SHP2;

    Abstract : Around 2000 persons are diagnosed with lymphoma in Sweden each year. There are many subgroups described for this form of cancer and the great majority is derived from B-cells. The most common subgroup is Diffuse large B-cell lymphoma (DLBCL), a highly aggressive disease where only half of the patients are cured. READ MORE

  2. 2. Functional collaboration between HLH transcription factors in B cell development

    University dissertation from Ramiro Gisler, Stem cell laboratory, BMC, B12, Klinikg.26, 22184 Lund, Sweden

    Author : Ramiro Gisler; Lunds universitet.; Lund University.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; E47; Early B cell Factor EBF ; Clinical genetics; Klinisk genetik; HLH proteins; transcription factors; gene expression; B cell development; transcription regulation;

    Abstract : Popular Abstract in Swedish Alla friska människor har 46 kromosomer, 23 av dessa härstammar från modern och 23 från fadern. Kromosomer är långa kedjor av nukleinsyror som innehåller den genetiska informationen (arvsanlagen) som behövs för att ett befruktat ägg skall kunna utvecklas till en individ bestående av miljontals celler med mycket specialiserade och avancerade uppgifter. READ MORE

  3. 3. Molecular Genetic Analysis in B-cell Lymphomas A Focus on the p53 Pathway and p16INK4a

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Norafiza Zainuddin; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diffuse large B-cell lymphoma; chronic lymphocytic leukemia; TP53 mutation; MDM2 SNP309; codon 72 polymorphism; p16INK4a methylation; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Molecular biology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Molekylärbiologi; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Haematology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Hematologi; MEDICINE Morphology; cell biology; pathology Morphology Tumour biology; MEDICIN Morfologi; cellbiologi; patologi Morfologi Tumörbiologi; Clinical Genetics; Klinisk genetik; Medical Genetics; Medicinsk genetik; Molekylär genetik; Molecular Genetics; Oncology; Onkologi; Pathology; Patologi;

    Abstract : The presence of TP53 mutations has been associated with inferior outcome in diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). In DLBCL, the impact of the TP53 codon 72 polymorphism and MDM2 SNP309 has not been clearly elucidated, whereas MDM2 SNP309 was suggested as a poor-prognostic marker in CLL. READ MORE

  4. 4. Genetics of diffuse large B-cell lymphoma

    University dissertation from Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Author : Konstantinos Georgiou; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Diffuse large B-cell lymphoma (DLBCL) is one the most common forms of non-Hodgkin lymphoma and one of the most aggressive B-cell neoplasms. Although most patients respond to current standard treatments, a significant number of them relapse and become refractory to treatment. Hence, there is a need for new approaches in the management of DLBCL. READ MORE

  5. 5. Stereotyped B Cell Receptors in Chronic Lymphocytic Leukaemia Implications for Antigen Selection in Leukemogenesis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Fiona Murray; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukaemia; immunoglobulin genes; somatic hypermutation; stereotyped B cell receptors; antigen selection; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Molecular biology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Molekylärbiologi;

    Abstract : Biased immunoglobulin heavy variable (IGHV) gene usage and distinctive B-cell receptor (BCR) features have been reported in chronic lymphocytic leukaemia (CLL), which may reflect clonal selection by antigens during disease development. Furthermore, the IGHV gene mutation status distinguishes two clinical entities of CLL, where patients with unmutated IGHV genes have an inferior prognosis compared to those with mutated IGHV genes. READ MORE