Search for dissertations about: "Lars Nilsson"
Showing result 6 - 10 of 132 swedish dissertations containing the words Lars Nilsson.
-
6. The enactment effect : studies of a memory phenomenon
Abstract : .... READ MORE
-
7. Soluble amyloid-β aggregates in Alzheimer’s disease
Abstract : Soluble oligomeric aggregates of the amyloid-β (Aβ) peptide are suggested to initiate Alzheimer's disease (AD), leading to impaired synapse signalling, widespread neuronal death and loss of cognitive functions. These aggregates seem tightly linked to disease progression, and have therefore gained much attention as potential novel disease markers. READ MORE
-
8. Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model
Abstract : The Arctic mutation causes early-onset Alzheimer’s disease (AD), and makes amyloid-β (Aβ) peptides more prone to form Aβ protofibrils. The aims of this thesis were to investigate the mechanisms of the Arctic mutation in vivo, and to use transgenic models to determine the role of early intermediates of Aβ aggregation, like protofibrils, in the pathogenesis. READ MORE
-
9. Screening for Cardiovascular Risk and Diabetes in Primary Health Care : The Söderåkra Risk Factor Screening Study
Abstract : Background: Cardiovascular disease (CVD) has been the predominant cause of morbidity and mortality for many decades in Sweden. Preventive work in primary health care through individual approach and community-based programmes has shown some success. READ MORE
-
10. Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation
Abstract : The Arctic mutation in the Amyloid-β (Aβ) domain of the Amyloid-β precursor protein (APP) causes Alzheimer’s disease (AD) and confers unique biochemical characteristics to Aβ peptides. The aims of this thesis were to evaluate a transgenic model with the Arctic mutation, and to use it to gain new insights into the mechanisms of early (pre-plaque) and late-stage Aβ pathogenesis in AD. READ MORE
