Search for dissertations about: "Lars Rönnblom"

Showing result 1 - 5 of 12 swedish dissertations containing the words Lars Rönnblom.

  1. 1. Studies on interferon producing human blood leukocytes

    Author : Lars Rönnblom; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  2. 2. Lupus Nephritis – Genetic Impact on Clinical Phenotypes, Disease Severity and Renal Outcome

    Author : Karin Bolin; Gunnel Nordmark; Lars Rönnblom; Inger Gjertsson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; Nephritis; Lupus Nephritis; Genetics; STAT4; BANK1; C1q Deficiency; Renal Insufficiency; End-Stage Renal Disease; Sex Differences; Medicinsk vetenskap; Medical Science;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that can affect every organ system. Lupus nephritis (LN) is one of the more serious SLE manifestations. Whilst the genetic background of SLE has been thoroughly investigated, less is known about the background of LN. READ MORE

  3. 3. Mechanisms of Interferon-α Induction in Systemic Lupus Erythematosus

    Author : Ullvi Båve; Lars Rönnblom; Gunnar V. Alm; Ingrid Lundberg; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Systemic lupus erythematosus; interferon inducer; apoptosis; autoantibodies; natural interferon-alpha producing cell; FcgammaRII; Sjögren´s syndrome; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicine; medicin;

    Abstract : Patients with systemic lupus erythematosus (SLE) have an activated type I interferon (IFN) system with an ongoing IFN-α synthesis. This may be caused by circulating immune complexes, consisting of anti-DNA antibodies (Abs) and DNA, with IFN-α inducing capacity. READ MORE

  4. 4. The Role of Plasmacytoid Dendritic Cells and Natural Killer Cells in Systemic Lupus Erythematosus

    Author : Niklas Hagberg; Lars Rönnblom; Maija-Leena Eloranta; George Tsokos; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; plasmacytoid dendritic cells; natural killer cells; type I interferon; immune complex; SLAM receptors; autoantibodies; CD94 NKG2A; CD94 NKG2C; Medicinsk vetenskap; Medical Science; Immunologi; Immunology;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, which can eventually lead to immune complex (IC)-mediated organ damage. Due to the stimulation of plasmacytoid dendritic cells (pDC) by nucleic acid-containing ICs (DNA- or RNA-IC), patients with SLE have an ongoing interferon (IFN)-α production. READ MORE

  5. 5. The activation and regulation of plasmacytoid dendritic cells in SLE : and possible therapeutic interventions

    Author : Karin Hjorton; Lars Rönnblom; Maija-Leena Eloranta; Hans Carlsten; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; pDCs; NK cells; interferon; autoantibodies; immune complex; hydroxychloroquine; IRAK4 inhibition;

    Abstract : Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by the presence of anti-nuclear antibodies and the formation of nucleic acid containing immune complexes (ICs), which can cause organ damage by deposition in tissues. ICs strongly trigger the plasmacytoid dendritic cells (pDCs) to produce interferon (IFN)-α, which potently activates the immune system. READ MORE