Search for dissertations about: "Late endosome"

Found 4 swedish dissertations containing the words Late endosome.

  2. 1. Connecting Systemic RNAi to the Endomembrane System in Caenorhabditis elegans

    Author : Benjamin T. Holmgren; Andrea Hinas; Gerhart Wagner; Peter Brodersen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; Endomembrane system; Late endosome; SID-5; SEC-22; SYX-6; C12D8.1; RNA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : RNA interference (RNAi) is a gene regulation mechanism conserved among eukaryotes. To silence gene expression, RNAi relies on a short single-stranded guide RNA to steer the RNA-induced Silencing Complex (RISC) to mRNAs with guide strand-complementary sequences. RNAi is a highly membrane-associated process. READ MORE

  4. 2. Systemic RNAi Relies on the Endomembrane System in Caenorhabditis elegans

    Author : Yani Zhao; Andrea Hinas; Staffan Svärd; Simon Tuck; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; late endosomes MVBs; SID-5; SEC-22; SYX-6; C12D8.1; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : The membrane system of a eukaryotic cell is a large and complex system handling the transport, exchange and degradation of many kinds of material. Recent research shows that double-stranded RNA (dsRNA) mediated gene silencing (RNA interference) is a membrane related process. READ MORE

  5. 3. In vitro characterization of nanodrugs at model lipid membranes

    Author : Rickard Frost; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; in vitro screening; nanomedicine; drug delivery; drug carrier; supported lipid bilayer; QCM-D; nanoparticle; cell membrane;

    Abstract : The use of nano-sized drug carriers to improve the efficiency of drug delivery has become well established during the past decades. New nanoparticle (NP) formulations for the administration of biopharmaceuticals (e.g. proteins and peptides) emerge at an increasing rate and the need for methods to evaluate their properties is expanding. READ MORE

  6. 4. Alzheimer disease : a super-resolved picture of the amyloid β-peptide producing machinery

    Author : Yang Yu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer disease (AD) is the most common neurodegenerative disease, influencing 40 million patients in the world. Pathologically, AD is hallmarked by intracellular tau tangles and extracellular Amyloid-β peptide (Aβ) plaques. Aβ is generated from the amyloid precursor protein (APP) and its C-terminal fragment (APP-CTF). READ MORE