Search for dissertations about: "Late response"

Showing result 1 - 5 of 382 swedish dissertations containing the words Late response.

  1. 1. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response

    Author : Fredrik Qvarnström; Ingela Turesson; Gunilla Enblad; Mats Harms-Ringdahl; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; Oncology; Onkologi; Oncology; onkologi;

    Abstract : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. READ MORE

  2. 2. Physiological Stress Reactivity in Late Pregnancy

    Author : Charlotte Hellgren; Inger Sundström-Poromaa; Helena Åkerud; Mats Hammar; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; acoustic startle response; allopregnanolone; antenatal; anxiety; cold pressor test; cortisol; cortisol awakening response; depression; electrodermal; estradiol; hypothalamic-pituitary-adrenal axis; postpartum; pregnancy; progesterone; skin conductance; stress; sympathetic nervous system; Medical Science; Medicinsk vetenskap;

    Abstract : During pregnancy, the basal activity is increased in both of our major stress response systems: the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. At the same time, the reactivity towards stressors is reduced. These alterations sustain maternal and fetal homeostasis, and are involved in the regulation of gestational length. READ MORE

  3. 3. Biomarker discovery and assessment for prediction of kidney response after 177Lu-octreotate therapy

    Author : Emil Schüler; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRRT; somatostatin; radionuclide therapy; 177Lu-octreotate; scintigraphy; renal function; toxicity; kidney response; radiation biology; microarray; molecular biomarkers; ionizing radiation; miRNA; proteomics; transcriptional response;

    Abstract : Patients suffering from neuroendocrine tumors are oftentimes presented with spread disease at the time of diagnosis. Therapy using somatostatin analogs is today the only potentially curative treatment option for these patients. READ MORE

  4. 4. The automation effect: Investigating factors that influence the driver response process in a safety-relevant event during assisted driving and after unsupervised automation

    Author : Linda Pipkorn; Chalmers University of Technology; []
    Keywords : TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; SAMHÄLLSVETENSKAP; ENGINEERING AND TECHNOLOGY; ENGINEERING AND TECHNOLOGY; ENGINEERING AND TECHNOLOGY; SOCIAL SCIENCES; driving performance; automated driving; driver behaviour; driver response; test track; take over; response process; automation;

    Abstract : Introduction: Safe vehicle automation can be achieved through a detailed understanding of drivers’ ability to respond to a safety-relevant event after a period of automated driving. For instance, there is a need to understand in which scenarios automation effects are present (e.g. delayed response, degraded driving performance, crashing). READ MORE

  5. 5. Modelling late toxicity in hypofractionated radiation therapy

    Author : Niclas Pettersson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; Göteborgs universitet; Gothenburg University; []
    Keywords : Hypofractionation; normal tissue complication probability; modelling; linear-quadratic model; fractionation sensitivity; late toxicity; radiation-induced rib fracture; genitourinary toxicity; stereotactic body radiation therapy; high-dose-rate brachytherapy; multimodality radiation therapy; patient-reported outcomes; prostate cancer; nsclc;

    Abstract : In hypofractionated radiation therapy (RT), the treatment is delivered by few fractions with high doses per fraction. This is in contrast to conventionally fractionated RT where the total dose is delivered in many fractions with low doses per fraction. READ MORE