Search for dissertations about: "Late response"

Showing result 6 - 10 of 398 swedish dissertations containing the words Late response.

  2. 6. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings

    Author : Martin Simonsson; Ingela Turesson; Gunilla Enblad; Dag Rune Olsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; dermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; gamma-H2AX; 53BP1; p21; checkpoint; apoptosis; mitosis; micro-RNA; miR-34a; Oncology; Onkologi; Oncology; Onkologi;

    Abstract : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. READ MORE

  4. 7. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data

    Author : Gustaf Wellhagen; Maria C. Kjellsson; Bengt Hamrén; Per Olsson Gisleskog; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; modelling; non-linear mixed effects modelling; composite scale data; total score data; total score analysis; precision prediction; bounded integer; bounded integer model; IRT-informed total score analysis; item response theory-informed; mixed models for repeated measures; MMRM; dose-response; dose-response mixed models for repeated measures; DR-MMRM; HbA1c models; fit-for-purpose analysis; clinical trial analysis; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. READ MORE

  5. 8. Late Quaternary climate and environmental change in the summer rainfall region of South Africa : A study using trees and wetland peat cores as natural archives

    Author : Elin Norström; Karin Holmgren; Michael Meadows; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; paleoclimate; Late Quaternary; pollen; stable isotopes; diatoms; phytoliths; dendroclimatology; South Africa; Physical geography; Naturgeografi; Physical Geography; naturgeografi;

    Abstract : This thesis contributes with information on past climate and environmental changes in South Africa’s summer rainfall region. The study is based on multi-proxy analyses on wetland peat cores and analyses of stable isotope composition (δ13C, δ18O) and wood anatomy in cross sections from subtropical trees (Breonadia salicina). READ MORE

  6. 9. Benthic environmental responses to climatic changes during the late Quaternary: a micropalaeontological and geochemical approach

    Author : Claire McKay; Kvartärgeologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; late Quaternary; rapid climate change; Benguela; Mauritania; productivity; upwelling; benthic foraminifera;

    Abstract : There is a limited understanding of how the benthic environment within upwelling regions responded to past rapid climatic changes. Within this thesis, a multiproxy approach is applied to two marine sediment cores from two coastal upwelling sites in the low latitude subtropical Atlantic. READ MORE

  7. 10. Testicular cancer – response adapted treatment, prognostic markers and survivorship issues

    Author : Sven-Erik Olofsson; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; testicular cancer; response adapted treatment; prognostic markers; survivorship; work ability; work loss; RBM3;

    Abstract : In the US and most European countries, testicular cancer is the most common malignancy in young men aged 20-40 years. Since the introduction of cisplatin-based treatment in the 1970s, more than 95% of the patients are cured. READ MORE