Search for dissertations about: "Lena Kjellén"

Showing result 1 - 5 of 13 swedish dissertations containing the words Lena Kjellén.

  1. 1. Studies on rat liver heparan sulfate proteoglycans

    Author : Lena Kjellén; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  2. 2. Directing Angiogenesis : Cellular Responses to Gradients in vitro

    Author : Irmeli Barkefors; Johan Kreuger; Lena Kjellén; Pär Gerwins; Ferdinand Le Noble; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Angiogenesis; Endothelial cell; Cell migration; Chemotaxis; Gradients; Microfluidics; VEGFA; VEGFR2; Exocyst; Exocytosis; Cell and molecular biology; Cell- och molekylärbiologi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Blood vessels are essential for the delivery of nutrients and oxygen to tissues, as well as for the removal of waste products. Patients with tumors, wounds or diabetes all have active angiogenesis, formation and remodeling of blood vessels, a process that is initiated and manipulated by gradients of secreted signaling proteins. READ MORE

  3. 3. Cellular design of heparan sulfate : The NDST enzymes and their regulation

    Author : Pernilla Carlsson; Lena Kjellén; Tarja Kinnunen; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; heparan sulfate; heparin; proteoglycan; NDST; PAPS; Golgi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. READ MORE

  4. 4. Role of Heparan Sulfate N-sulfation in Mouse Embryonic Development

    Author : Anders Dagälv; Lena Kjellén; Svein Kolset; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; heparan sullfate; heparin; proteoglycan; NDST1; NDST2; coreprotein; syndecan; Biochemistry; Biokemi; Cell biology; Cellbiologi; Biokemi; Biochemistry;

    Abstract : Heparan sulfate (HS) is a sulfated glycosaminoglycan expressed by all cells in the body. It is found at the cell surface and in the extracellular matrix where it binds a large amount of various ligands including growth factors and morphogens. READ MORE

  5. 5. Implications of Heparan Sulfate and Heparanase in Inflammatory Diseases

    Author : Andreas Digre; Jin-Ping Li; Lena Kjellén; Liliana Schaefer; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Heparanase; Heparan sulfate; Inflammation; Inflammatory diseases; Autoimmune diseases; Amyloidosis; Reumathoid arthritis; SAA; APP; A beta; Neuroinflammation; Medical Science; Medicinsk vetenskap; Medical Biochemistry; Medicinsk biokemi; Immunologi; Immunology; Neurology; Neurologi;

    Abstract : Heparan sulfate (HS), an unbranched sulfated carbohydrate chain, and the HS-degrading enzyme heparanase play important roles in physiological and pathological processes during all stages of life, from early embryogenesis to ageing. Accumulated information shows that HS and heparanase are involved in inflammatory processes and associated diseases, e. READ MORE