Search for dissertations about: "Lena Nielsen"

Found 4 swedish dissertations containing the words Lena Nielsen.

  2. 1. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies

    Author : Elisabet I Nielsen; Lena E Friberg; Otto Cars; Mats O Karlsson; Marie Sandström; Alan Forrest; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; NONMEM; antibiotics; in vitro; time-kill curve; PK PD indices; gentamicin; aminoglycosides; newborn infants; premature infants; cystatin C; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. READ MORE

  4. 2. Pharmacometric Evaluation of Biomarkers to Improve Treatment in Oncology

    Author : Ida Netterberg; Lena Friberg; Mats Karlsson; Elisabet I. Nielsen; Henrik Lindman; Amit Roy; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Biomarkers; Oncology; Population PKPD Modeling; NONMEM; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Cancer is a family of many different diseases with substantial heterogeneity also within the same cancer type. In the era of personalized medicine, it is desirable to identify an early response to treatment (i.e., a biomarker) that can predict the long-term outcome with respect to both safety and efficacy. READ MORE

  5. 3. Pharmacometrics to characterize innate immune response and antibacterial treatments

    Author : Anders Thorsted; Lena E. Friberg; Elisabet I. Nielsen; Mats O. Karlsson; Gauri G. Rao; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; non-linear mixed effects modelling; modelling; pharmacokinetics; pharmacodynamics; pkpd; antibiotics; cefuroxime; piperacillin; phagocytes; lipopolysaccharide; endotoxin; porcine endotoxemia; challenge studies; sepsis; critically ill; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The immune system protects the host against pathogens by distinguishing self from non-self. However, it is most-often disregarded in pharmacokinetic-pharmacodynamic (PKPD) characterization of (new and old) antibiotics. READ MORE

  6. 4. Quantifying effects of antimicrobial drug combinations by modelling and simulation

    Author : Chenyan Zhao; Lena Friberg; Elisabet I. Nielsen; Shampa Das; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics and pharmacodynamics; modelling and simulation; antibiotic combination; model-based translation; antibiotic resistance; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Antibiotic resistance is becoming an accelerating issue, both in the treatment of nosocomial infections and for public health in general. There is a pressing need for innovative methods to understand how available antibiotics could be combined to overcome and limit the emergence of resistance. READ MORE