Search for dissertations about: "Leon Aarons"
Found 2 swedish dissertations containing the words Leon Aarons.
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1. Methodology for Handling Missing Data in Nonlinear Mixed Effects Modelling
Abstract : To obtain a better understanding of the pharmacokinetic and/or pharmacodynamic characteristics of an investigated treatment, clinical data is often analysed with nonlinear mixed effects modelling. The developed models can be used to design future clinical trials or to guide individualised drug treatment. READ MORE
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2. Estimation of Dosing Strategies for Individualisation
Abstract : To increase the proportion of patients with successful drug treatment, dose individualisation on the basis of one or several patient characteristics, a priori individualisation, and/or on the basis of feedback observations from the patient following an initial dose, a posteriori individualisation, is an option. Efficient tools in optimising individualised dosing strategies are population models describing pharmacokinetics (PK) and the relation between pharmacokinetics and pharmacodynamics (PK/PD). READ MORE