Search for dissertations about: "Leukemia and its types thesis"

Showing result 1 - 5 of 16 swedish dissertations containing the words Leukemia and its types thesis.

  2. 1. Wilms' tumor gene 1 in different types of cancer

    Author : Xingru Li; Aihong Li; Karin Nylander; Eva Lundin; Xiaolian Gu; David M. Loeb; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; WT1; AML; MRD; ccRCC; SNPs; DNA methylation; SCCHN; p63; Clinical Chemistry; klinisk kemi;

    Abstract : The Wilms’ tumor gene 1 (WT1) was first reported as a tumor suppressor gene in Wilms’ tumor. However, later studies have shown the oncogenic properties of WT1 in a variety of tumors. It was recently proposed that WT1 was a chameleon gene, due to its dual functions in tumorigenesis. READ MORE

  4. 2. Nucleoside analoge cytotoxicity-focus on enzyme regulation, metabolism, and mechanisms of resistance

    Author : Anna Fyrberg; Kourosh Lotfi; Curt Peterson; Freidoun Albertioni; Francoise Bontemps; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Farmakologi;

    Abstract : The aim of this thesis was to determine the role of nucleoside analog activating and deactivating enzymes in nucleoside analog metabolism and resistance development. Nucleoside analogs are anti-cancer drogs and are often used to treat different leukemias, attributably to presence of high levels of nucleoside analog activating enzymes in hematopoietic cells. READ MORE

  5. 3. Selenocompounds in leukemia treatment : advantages and pitfalls

    Author : Wenyi Zheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In 2018, cancer was reported to be the second top cause of morbidity and mortality globally with over 9 million deaths. Hematological malignancies including leukemia constitute about 7% of the total cancer cases. READ MORE

  6. 4. Genetic analyses of multiple myeloma and related plasma cell dyscrasias

    Author : Therese Nilsson; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetik; cytogenetik; cytogenetics; Genetics; FISH; cytogenetic; multiple myeloma; MGUS;

    Abstract : Acquired genetic changes have proved to be of diagnostic and prognostic importance in different hematologic malignancies as well as in some solid tumor types. However, although multiple myeloma (MM), an incurable disease, and its proceeding stage monoclonal gammopathy of undetermined significance (MGUS) are quite common, little is known about the karyotypic features of these plasma cell dyscrasias. READ MORE

  7. 5. C-Kit as an Oncogenic Tyrosine Kinase - Regulation and Dysregulation of Signaling Pathways

    Author : Malin Pedersen; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : It is well known that increased growth and survival of cancer cells often is a result of dysregulated kinase activity and aberrant kinase signaling. The receptor tyrosine kinase c-Kit and its ligand SCF are contributors to this phenomenon in a variety of human cancers, for example hematological malignancies, germ cell tumors and gastrointestinal stromal tumors. READ MORE