Search for dissertations about: "Leukemia in pediatrics"

Showing result 1 - 5 of 9 swedish dissertations containing the words Leukemia in pediatrics.

2. 1. Associated disorders in celiac disease

   Author : Peter Elfström; Jonas F. Ludvigsson; Anders Ekbom; Peter Green; Örebro universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addison; autoimmune; biopsy; celiac; child; cohort study; cancer; heart; liver; lymphoma; thyroid; Paediatric medicine; Pediatrisk medicin; MEDICINE; MEDICIN; Pediatrik; Pediatrics; Epidemiology; Epidemiologi; Medicin; Medicine;

   Abstract : Background: Celiac disease (CD) is an autoimmune disorder that affects genetically susceptible individuals and is induced by dietary gluten. Treatment consists of a lifelong gluten-free diet. CD is common and affects about 1% of the general population. READ MORE

4. 2. DNA methylation as a prognostic marker i acute lymphoblastic leukemia

   Author : Magnus Borssén; Sofie Degerman; Kim Vettenranta; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; acute lymphoblastic leukemia; T-ALL; Relapse; Telomere length; patologi; Pathology; Pediatrics; pediatrik;

   Abstract : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Most ALL cases originate from immature B-cells (BCP-ALL) and are characterized by reoccurring structural genetic aberrations. These aberrations hold information of the pathogenesis of ALL and are used for risk stratification in treatment. READ MORE

5. 3. Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia

   Author : Josefine Palle; Gudmar Lönnerholm; Britt-Marie Frost; Rolf Larsson; Henrik Schröder; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood; acute myeloid leukemia; drug resistance; pharmacokinetics; chromosomal abnormalities; Down syndrome; MLL-rearrangement; t 9; 11 ; Paediatric medicine; Pediatrisk medicin;

   Abstract : Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML. READ MORE

6. 4. Gene Expression and DNA Methylation in Acute Lymphoblastic Leukemia

   Author : Jessica Nordlund; Syvänen Ann-Christine; Xavier Estivill; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Digital gene expression; Allele-specific gene expression; DNA methylation; Epigenetics; Acute lymphoblastic leukemia; Molekylär medicin; Molecular Medicine;

   Abstract : Pediatric acute lymphoblastic leukemia (ALL) is the most common malignancy in children, which results from the malignant transformation of progenitor cells in the bone marrow into leukemic cells. The precise mechanisms for this transformation are not well defined, however recent studies suggest that aberrant regulation of gene expression or DNA methylation may play an important role. READ MORE

7. 5. Vitamin D, bone turnover markers and hCAP-18 in children with hemato-oncological diseases

   Author : Natalja Jackmann; Per Frisk; Outi Mäkitie; Jan Gustafsson; Anna Sällfors Holmqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vitamin D; pediatric cancer; leukemia; bone marrow failure; hCAP-18; bone turnover markers; Medicinsk vetenskap; Medical Science;

   Abstract : Children with hemato-oncological diseases may have significant skeletal morbidities. Vitamin D is essential for the maintenance of skeletal health and may also be important for immunological functions and cancer outcomes. READ MORE