Search for dissertations about: "Leukemia microarray"
Showing result 1 - 5 of 21 swedish dissertations containing the words Leukemia microarray.
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1. Gene Expression Studies of Hematologic Malignacies
Abstract : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. READ MORE
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2. Classification and Computational Methods in Gene Expression Data Analysis
Abstract : The technology of cDNA microarrays has given us the possibility to monitor the state of cells by measuring the activity of thousands of genes simultaneously. This high-throughput techniqe has in cancer research allowed exploratory studies of molecular mechanisms behind for example metastasis and response to therapy. READ MORE
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3. Probalistic Methods In Genomic Data Analysis
Abstract : In this thesis, three aspects of gene expression data analysis are discussed: Differential gene expression is addressed by a probabilistic method. Gene annotation enrichment analysis is discussed in the context of multiple hypothesis testing and the choice of null hypothesis. READ MORE
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4. Clinical and Experimental Studies in Chronic Myeloid Leukemia : Studies of Treatment Outcome, In Vitro Cellular Drug Resistance and Gene Expression
Abstract : The aims of the studies described in the thesis were to investigate different treatment strategies in chronic myeloid leukemia (CML) patients. Furthermore, activity of imatinib was investigated by in vitro cytotoxicity assay, and the gene expression pattern in interferon treated patients. READ MORE
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5. Array based genetic profiling of chronic lymphocytic leukemia
Abstract : Although no common genetic defect has been described in chronic lymphocytic leukemia (CLL), recurrent genomic aberrations (i.e. deletions of chromosome 11q, 13q, 17p and trisomy 12) are important for prognostication. Deletion of 13q as single aberration is associated with the best prognosis, whereas del(11q) and del(17p) predict a poor outcome. READ MORE