Search for dissertations about: "Lewis antigens"

Showing result 1 - 5 of 28 swedish dissertations containing the words Lewis antigens.

  1. 1. Helicobacter pylori adhesion and patho-adaptation : the role of BabA and SabA adhesins in persistent infection and chronic inflammation

    Author : Jafar Mahdavi; Henrik Clausen; Umeå universitet; []
    Keywords : H. pylori; BabA; adhesin; Lewis b; MUC5AC; sialyl-dimeric-Lewis x; chronic inflammation; SabA; Lewis x; LPS; odontologi; Odontology;

    Abstract : Helicobacter pylori (H. pylori) is a human-specific gastric pathogen which is responsible for a spectrum of diseases ranging from superficial gastritis to gastric and duodenal ulceration, and which is also highly associated with gastric cancer. The pathogenesis of severe gastric disorders caused by H. READ MORE

  2. 2. Synthetic analogs of sialyl Lewis x

    Author : Ulf Ellervik; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stereoselective synthesis; regioselective synthesis; lactam analogs; lactone; Selectin; Sialyl Lewis x; SLex; Organic chemistry; Organisk kemi;

    Abstract : The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. READ MORE

  3. 3. Herpesvirus-induced expression of sLe(x) and related O-linked glycans in the infected cell

    Author : Kristina Nyström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HSV-1; CMV; VZV; O-linked glycans; Lewis antigens; ICP0;

    Abstract : Lewis antigens constitute a family of fucosylated carbohydrate antigens (glycotopes), involved in leukocyte homing and related immunological phenomena. These glycotopes are only expressed restrictedly in normal cells, but are induced at appropriate occasions. It is well established that many tumors ?hijack? Lewis glycotopes for e.g. READ MORE

  4. 4. Synthesis of biologically active oligosaccharides of the Lewis b family and investigations towards the synthesis of glycoclusters

    Author : Linnéa Skantz; Martina Lahmann; Thisbe Lindhorst; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Lewis b; lactosamine; dendrimers; oxazolidinone; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Abstract : The gastric pathogen Helicobacter pylori is a Gram negative bacterium which may cause diseases such as peptic ulceration and gastric adenocarcinoma. It colonises a host by attaching to the gastric epithelial cells, an attachment mediated by outer membrane proteins on the bacterial surface, e.g, the blood group antigen binding adhesin, BabA. READ MORE

  5. 5. Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans

    Author : Jonas Löfling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Fucose; Lewis antigen; Blood group ABH; biosynthesis;

    Abstract : ABH and Lewis antigens are carbohydrate epitopes (glycans) found on a wide variety of cell surfaces. They are involved in many biological processes, e.g transplantation rejection, bacterial and viral adhesion, cell-cell communication and metastasis. The in vivo synthesis of glycans is mediated by glycosyltransferases (GTs). READ MORE