Search for dissertations about: "Lhx2"

Showing result 1 - 5 of 7 swedish dissertations containing the word Lhx2.

  2. 1. The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems

    Author : Åsa Kolterud; Leif Carlsson; Stefan Thor; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; LIM-homeobox gene; Lhx2; fetal liver; hepatic stellate cells; hematopoietic stem cells; septum transversum; self-renewal; odorant receptor genes; olfactory epithelium; olfactory sensory neuron; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Abstract : During embryonic development a variety of tissues and organs such as the lung, eye, and kidney are being formed. The generation of functional organs is regulated by reciprocal cell-cell interactions. Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. READ MORE

  4. 2. Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development

    Author : Lina Dahl; Leif Carlsson; Jan-Ingvar Jönsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lhx2; hematopoietic system; hematopoietic stem cell; progenitor; embryonic stem cell; embryoid body; eye development; forebrain; eye field transcription factor; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Abstract : When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. READ MORE

  5. 3. Molecular and cellular analysis of Lhx2 function in hematopoietic stem cells

    Author : Karin Richter; Leif Carlsson; Andrew Elefanty; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hematopoietic stem cells; Lhx2; cell lines; self renewal; SCF; IL-6; chronic myeloproliferative disorder; global gene expression analysis; Molecular biology; Molekylärbiologi;

    Abstract : The formation of blood, hematopoiesis, is a dynamic process originating from a small number of hematopoietic stem cells (HSCs). To sustain hematopoiesis throughout life HSCs have the unique capacity to differentiate into all mature hematopoietic lineages as well as generating more HSCs by a mechanism referred to as self-renewal. READ MORE

  6. 4. The role of Lhx2 in the hematopoietic stem cell function, liver development and disease

    Author : Ewa Wandzioch; Leif Carlsson; Stephen A Duncan; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; liver fibrosis; liver development; Lhx2; hematopoietic stem cells; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molecular cell biology; molekylär cellbiologi;

    Abstract : During embryonic development, generation of functional organs is dependent on proper interactions between different cell types. Elucidation of the mechanisms operating during organ formation might provide insights into the origin of many pathological disorders in the adult. READ MORE

  7. 5. The role of Lhx2 in hair follicle morphogenesis and regeneration

    Author : Gunilla Törnqvist; Leif Carlsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; molecular cell biology; molekylär cellbiologi;

    Abstract : Hair is important for thermoregulation, physical protection, sensory activity, seasonal camouflage and social interactions. Hair is produced in hair follicles (HFs), complex mini-organs in the skin devoted to this task. READ MORE