Search for dissertations about: "Liang Zhang"

Found 3 swedish dissertations containing the words Liang Zhang.

  2. 1. Antiapoptotic effect of ouabain in renal cells exposed to toxic glucose levels

    Author : Liang Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetes mellitus is a group of metabolic diseases that causes enormous social and economic burden. The kidney is the filtration organ that produces urine and is the primary target of diabetic complications, a condition called diabetic nephropathy (DN). READ MORE

  4. 2. Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

    Author : Liang Zhang; Véronique Chotteau; Michael J. Betenbaugh; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary cells; glycosylation; IgG; mathematical modelling; experimental design; perfusion; carbon sources; GReBA; Bayesian network; probabilistic graphic model; Bioteknologi; Biotechnology;

    Abstract : Chinese hamster ovary (CHO) cells are the most popular expression system for the production of biopharmaceuticals. More than 80% of the approved monoclonal antibodies (mAbs) or immunoglobulin G (IgG) are produced with these cells. Glycosylation is a usual post- translational modification important for therapeutic mAbs. READ MORE

  5. 3. In silico Identification of Thyroid Disrupting Chemicals : among industrial chemicals and household dust contaminants

    Author : Jin Zhang; Patrik Andersson; A. Elisabeth Sauer-Eriksson; Liang-Hong Guo; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thyroid disruption chemicals; virtual screening; tranthyretin; thyroid hormone receptor; QSAR modeling; molecular docking; molecular dynamics;

    Abstract : Thyroid disruptions by xenobiotics have been associated with a broad spectrum of severe adverse human health effects, such as impaired brain development and metabolic syndrome. Ingestion of indoor dust and contact with industrial chemicals are two significant human exposure routes of thyroid hormone disrupting chemicals (THDCs), raising serious concerns for human health. READ MORE