Search for dissertations about: "Linda Söderberg"
Found 3 swedish dissertations containing the words Linda Söderberg.
-
1. Characterization of the Alzheimer's disease-associated clac protein
Abstract : Alzheimer's disease (AD) is the most prevalent form of dementia in elderly people and is neuropathologically characterized by the presence of extracellular senile plaques (SPs) in the brain. SPs are mainly composed of the amyloid beta-peptide (Abeta), proteolytically derived from the amyloid beta-precursor protein by sequential cleavages performed by beta- and gammasecretase, to generate Abeta species of 40 and 42 amino acids, respectively. READ MORE
-
2. Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay
Abstract : A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. READ MORE
-
3. Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes
Abstract : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. READ MORE