Search for dissertations about: "Linear mixed models"
Showing result 21 - 25 of 151 swedish dissertations containing the words Linear mixed models.
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21. Pharmacometric Models in Anesthesia and Analgesia
Abstract : Modeling is a valuable tool in drug development, to support decision making, improving study design, and aid in regulatory approval and labeling. This thesis describes the development of pharmacometric models for drugs used in anesthesia and analgesia. READ MORE
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22. Aerodynamic Design and Aeromechanical Analysis of Mixed and Radial Flow Turbines : A study on meanline method, stator tilting endwall design and forced response analysis
Abstract : In this energy transition era, turbocharging is still an important technology for the automotive industry to reduce fuel consumption and lower emissions in its vehicles. This importance can be seen from both conventional fossil-fuel powertrains, and emerging applications, such as increased utilization of biofuels along with hydrogen fuel cells. READ MORE
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23. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses
Abstract : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. READ MORE
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24. Analysis of factorial experiments using mixed-effects models: options for estimation, prediction and inference
Abstract : In linear mixed-effects modelling of experiments, estimation of variance components, prediction of random effects, and computation of denominator degrees of freedom associated with inference on fixed effects, are important elements of the analysis. This thesis investigates alternatives to the likelihoodbased procedures for analysis of factorial experiments with normally distributed observations. READ MORE
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25. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies
Abstract : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. READ MORE