Search for dissertations about: "Lipotoxicity"

Showing result 1 - 5 of 17 swedish dissertations containing the word Lipotoxicity.

  1. 1. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    University dissertation from Units of Epigenetics and Diabetes and Molecular Metabolism, Department of Clinical Sciences, Malmö

    Author : Siri Malmgren; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Abstract : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. READ MORE

  2. 2. Hormone-Sensitive Lipase and the Pancreatic Beta-Cell

    University dissertation from Department of Cell and Molecular Biology, Lund University

    Author : Håkan Lindvall; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetik; cytogenetics; Genetik; Genetics; cloning; gene expression; lipase; insulin secretion; diabetes; lipotoxicity;

    Abstract : Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization. It is acutely regulated by extracellular signals via reversible phosphorylation. In the recent past, the focus of type 2 diabetes research has moved towards the lipid component. READ MORE

  3. 3. Perilipin expression in the islets of Langerhans and Surface expression in the baculovirus/insect cell system

    University dissertation from Jörgen Borg BMC C11 22184 Lund

    Author : Jörgen Borg; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biology; Biologi; lipotoxicity; beta-cell; perilipin; amino-terminal anchor; Baculovirus; surface display;

    Abstract : Surface display in insect cells: Systems available for surface display that utilize bacterial phages are insufficient for displaying a number of eukaryotic proteins. By instead presenting proteins on the surface of eukaryotic cells or virus, some of these problems might be overcome. READ MORE

  4. 4. Effects of Free Fatty Acids on Insulin and Glucagon Secretion – with special emphasis on the role of Free fatty acid receptor 1

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hjalti Kristinsson; Peter Professor; Birgitte Holst; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FFAR1; GPR40; palmitate; lipotoxicity; islets of Langerhans; type 2 diabetes; obesity; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Prevalence of type 2 diabetes mellitus (T2DM) is still rising and even so in the juvenile population. Obesity is highly associated with increased risk for developing T2DM. READ MORE

  5. 5. Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Sandra Meidute; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hormone secretion; cell stress; Pancreatic beta-cell; cellular signalling; GPR40; diabetes;

    Abstract : Although it has been known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-cell function during both short-term as well as long-term exposure. READ MORE