Search for dissertations about: "Lipotoxicity"

Showing result 16 - 20 of 21 swedish dissertations containing the word Lipotoxicity.

  2. 16. Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs

    Author : Emilia Heimann; Signaltransduktionsforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; type 2 diabetes; islets of Langerhans; adipocytes; PDE3B; OPN; SCFAs;

    Abstract : Type 2 diabetes (T2D) is a heterogeneous disease characterized by altered lipid parameters and elevated glucose levels, as a direct consequence of impaired insulin signaling in target tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. READ MORE

  4. 17. Role of GLP-1 receptor agonists in endothelial function

    Author : Özlem Erdogdu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Type 2 diabetes;

    Abstract : BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis. Hence, there is a need for finding glucose-lowering agents that cause direct positive effects on vasculature in diabetic patients. READ MORE

  5. 18. Sex-different control of hepatic metabolism in relation to insulin sensitivity

    Author : Carolina Gustavsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The liver is a key metabolic organ. The liver has adapted to the different metabolic needs in men and women, and therefore responds in a sex-specific manner to various stimuli. READ MORE

  6. 19. Lifestyle and glycaemic control before and after the onset of type 2 diabetes

    Author : Robert Koivula; Genetisk och molekylär epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Prediabetes; Obesity; Beta-cell Function; Insulin Sensitivity; Physical Activity; Exercise; Diet; Lifestyle; Ectopic Fat; Genetic Epidemiology; Genetic Risk; Biomarker; Precision Medicine;

    Abstract : Type 2 diabetes (T2D) is a complex disease with widespread physiological insults to the regulation of metabolic homeostasis, above all glycaemic regulation. The pathogenesis of T2D and its progression is broadly understood to be through a gradual decrease in peripheral insulin sensitivity, a compensatory rise in insulin secretion, and a gradual decline in beta-cell function, resulting in glycaemic dysregulation and eventual T2D. READ MORE

  7. 20. Genetic and functional studies of MTTP and PLIN2 in relation to metabolic and cardiac dysfunction

    Author : Anna Aminoff; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Lipids including triglycerides, cholesterol, cholesterol esters and fatty acids are important sources for energy production, act as building blocks for intracellular compartments, are involved in numerous biological pathways and may act as signal molecules. Lipids are transported in blood as lipoproteins between organs, where they are immediately used in cellular processes or stored as cytosolic lipid droplets. READ MORE