Search for dissertations about: "Liquid Chromatography Tandem Mass Spectrometry"

Showing result 11 - 15 of 75 swedish dissertations containing the words Liquid Chromatography Tandem Mass Spectrometry.

  2. 11. Chemometrics : Unravelling information from complex data generated by modern instruments

    Author : Pedro F. M. de Sousa; Magnus Åberg; Johan Trygg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Chromatography; Mass spectrometry; DIA; PCA; PLS; Experimental Design; DNA; adductomics; Analytical Chemistry; analytisk kemi;

    Abstract : Chemometrics is a discipline dedicated to solving problems arising from complicated analytical systems, combining statistics, mathematics, and computational programming languages.This thesis is based on the work developed in four scientific projects published as papers in scientific journals. READ MORE

  4. 12. Liquid Chromatography-Mass Spectrometry as a Tool for Drug Metabolite Identification in Biological Fluids : With Application to Ketobemidone

    Author : Ingela Sundström; Per Andrén; Douglas Westerlund; Monika Johansson; Uppsala universitet; []
    Keywords : Analytical chemistry; LC-MS MS; accurate mass measurement; drug metabolites; microdialysate; brain; fluorinated stationary phase; phenylboronic acid; retention mechanism; Analytisk kemi;

    Abstract : Electrospray ionization (ESI) mass spectrometry (MS) in combination with liquid chromatography (LC) is an excellent tool for the identification of drug metabolites. Utilizing this hyphenated technique in combination with proper sample pretreatment, the metabolic pathways of the analgesic drug ketobemidone were investigated in human urine and rat microdialysate from blood and brain. READ MORE

  5. 13. Mass Spectrometry of Non-protein Amino Acids : BMAA and Neurodegenerative Diseases

    Author : Liying Jiang; Leopold Ilag; Jonas Bergquist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Neurodegenerative diseases; BMAA; Isomers; LC-MS MS; Cyanobacteria; Diatoms; Seafood contamination; Analytical Chemistry; analytisk kemi;

    Abstract : Neurodegenerative diseases have been shown to correlate positively with an ageing population. The most common neurodegenerative diseases are amyotrophic lateral sclerosis (ALS), Parkinson’s disease and Alzheimer’s disease. READ MORE

  6. 14. Mass spectrometric analyses of proteoglycans - Novel tools for studying prohormones in insulin-producing cells

    Author : Mahnaz Nikpour; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteoglycan; glycosaminoglycan; mass spectrometry; secretory granule; prohormones; CRISPR Cas9;

    Abstract : Proteoglycans (PGs) are proteins that carry one or more negatively charged glycosaminoglycan (GAG) chains. Proteoglycans have been identified in essentially all multicellular organisms, and are implicated in a wide range of biological and pathological processes. READ MORE

  7. 15. On the investigation of chemical parameters reflecting microbial activity linked to nutrient availability in forest soil

    Author : Madelen Olofsson; Dan Bylund; Bengt-Gunnar Jonsson; Bjarne W. Strobel; Mittuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Boreal forest; electrospray ionization; fungal biomass; hydrophilic interaction chromatography; hydroxamate siderophores; liquid chromatography-mass spectrometry; mineral amendment; aromatic acids; podzol soil;

    Abstract : As agrarian society developed, the most fertile soils able to sustain the nutritional requirements needed for high crop yield were assigned to farming, while the more penurious soils were left to uphold the forest ecosystems. Some temperate forests are developed on acidic soils considered to be nutrient poor, as much of the inorganic nutrients are entrapped in poorly weatherable soil minerals and not easily accessed by plant roots. READ MORE