Search for dissertations about: "Lisa K. Thalén"

Found 2 swedish dissertations containing the words Lisa K. Thalén.

  2. 1. Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines and Allylic Alcohols : The Preparation of Pharmaceutically Important Compounds

    Author : Lisa K. Thalén; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  4. 2. Transition Metal- and Enzyme-Catalyzed Reactions of Primary Amines and Allylic Alcohols : Powerful Tools in the Preparation of Pharmaceutically Important Compounds

    Author : Lisa K. Thalén; Jan-Erling Bäckvall; Dirk De Vos; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dynamic kinetic resolution; racemization; catalysis; hydrogen transfer; kinetic resolution; norsertraline; alpha-methyl carboxylic acids; pipecoloxylidide; organisk kemi; Organic Chemistry;

    Abstract : Dynamic kinetic resolution (DKR) has been applied to primary amines utilizing a ruthenium catalyst and an (R)-selective lipase to provide the corresponding amides in up to 95% isolated yield and up to >99% ee. Further investigations of the chemoenzymatic DKR of amines show that it is general and can be applied to a wide range of amines. READ MORE