Search for dissertations about: "Local insulin"

Showing result 1 - 5 of 83 swedish dissertations containing the words Local insulin.

  2. 1. Insulin and IGF-I in type 1 diabetes

    Author : Christina Hedman; Claes-Göran Östenson; Linköpings universitet; []
    Keywords : Type I diabetes; IGF-I; IGF system; insulin; insulin analogues; MEDICINE; MEDICIN;

    Abstract : Patients with type I diabetes have alterations in the GH/IGF system with reduced levels of circulating IGF-I, as well as other disturbances in the components of the IGF system.Alterations of both local and circulating IGF-I and its binding proteins (IGFBPs) have been associated with metabolic and vascular manifestations of diabetes and also with atherosclerosis. READ MORE

  4. 2. Insulin-coated titanium implants - a potential therapy for local bone regeneration

    Author : Behnosh Öhrnell Malekzadeh; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin; Titanium; Bone; Implant; Osteoblast; Immobilisation;

    Abstract : Background: Insulin is a hormone that regulates glucose metabolism, however, it is also important for bone formation. The anabolic effect of insulin on bone could open up alternative therapies when it comes to local bone regeneration. However, this requires a method for local administration of insulin. READ MORE

  5. 3. Insulin resistance in skeletal muscle. With special reference to interstitial insulin and glycerol

    Author : Mikaela Sjöstrand; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin resistance; skeletal muscle; microdialysis; interstitial insulin; interstitial glycerol;

    Abstract : Insulin resistance is a central feature of type 2 diabetes and obesity and is associated with cardiovascular disease. In insulin-resistant muscle, the insulin-mediated glucose uptake is decreased.The delivery of insulin to the interstitial fluid of human skeletal muscle has previously not been investigated. READ MORE

  6. 4. Lipid Signalling Dynamics in Insulin-secreting β-cells

    Author : Anne Wuttke; Anders Tengholm; Erik Gylfe; Louis Philipson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; β-cell; diacylglycerol; insulin secretion; oscillations; PtdIns 4 P; PtdIns 4; 5 P2; protein kinase C; P2Y receptor; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Certain membrane lipids are involved in intracellular signalling processes, among them phosphoinositides and diacylglycerol (DAG). They mediate a variety of functions, including the effects of nutrients and neurohormonal stimuli on insulin secretion from pancreatic β-cells. READ MORE

  7. 5. Membrane lipids and their transfer proteins in β-cells

    Author : Beichen Xie; Olof Idevall-Hagren; Anders Tengholm; Jen Liou; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ca2 ; PKC; E-Syt1; TMEM24; ER-PM contact; PI 4; 5 P2; phosphoinositides; β-cell; insulin; optogenetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. READ MORE