Search for dissertations about: "Localized prostate cancer"

Showing result 1 - 5 of 46 swedish dissertations containing the words Localized prostate cancer.

2. 1. Localized Prostate Cancer : Results From a Randomized Clinical Trial

   Author : Anna Bill-Axelson; Lars Holmberg; Bo Johan Norlén; Peter Wiklund; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; prostate cancer; localized; randomized; biopsies; interviews; Kirurgi; Surgery; Kirurgi;

   Abstract : The aims of the thesis were to• explore whether radical prostatectomy is beneficial compared with watchful waiting in survival and disease progression• find possible effect modifiers• evaluate a protocol of multiple biopsies and investigate if men with previous benign prostate biopsies are a group at risk for later prostate cancer• inquire into patients’ and clinicians’ experiences of randomization in order to find out what made this study possible to conduct, and thereby contribute to improve randomization in the futureThe background material was a large randomized clinical trial, the Scandinavian Prostatic Cancer Group Study Number 4, or SPCG-4, which was open for inclusion from February 1989 through December 1999. It comprised 695 men in Sweden, Finland and Iceland who had localized prostate cancer and were randomized to either radical prostatectomy or watchful waiting. READ MORE

4. 2. Role of Wnt5a in Prostate Cancer

   Author : Azharuddin Sajid Syed Khaja; Malmö Urologisk cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate Cancer; Wnt5a; tissue micro array; Biochemical recurrence; Gene fusions;

   Abstract : Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays important roles in organ development and tissue orientation. Previous studies have reported that Wnt5a was upregulated at both mRNA and protein levels in prostate cancer, but information regarding its role in predicting clinical outcome in patients after radical prostatectomy is limited. READ MORE

5. 3. Image analysis of prostate cancer tissue biomarkers

   Author : Giuseppe Lippolis; Malmö Urologisk cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; image analysis; Time Resolved Fluorescence; automated Gleason; PSA; AR; fusion gene; TMAs;

   Abstract : Prostate cancer is the second most common cancer in men. In order to improve diagnosis and prognosis, new sensitive and specific biomarkers are needed. Tissue biomarkers carry expression and morphological information of the tissue where they are expressed. READ MORE

6. 4. Quality of life and side effects in patients with localized prostate cancer : evaluation with self-assessment questionnaires

   Author : Per Fransson; Sten Nilsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; radiotherapy; complications; self assessment; questionnaires; validation; deferred treatment; quality of life;

   Abstract : Localized prostate cancer (LPC) is predominantly a tumor among older men, and few patients will get symptoms from the disease. All methods to treat LPC with a curative intent have different types and degrees of side effects. READ MORE

7. 5. Diet and Gastrointestinal Symptoms in Patients with Prostate Cancer Treated with Radiotherapy

   Author : Anna Pettersson; Ingela Turesson; Birgitta Johansson; Christina Persson; Clare Shaw; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dietary intervention; gastrointestinal symptoms; prostate cancer; radiotherapy; randomized controlled trial; health-related quality of life; questionnaire design; nutritional assessment; Medicinsk vetenskap; Medical Science;

   Abstract : Objective The main objective of this thesis was to explore the effects of diet on gastrointestinal symptoms in prostate cancer patients treated with local curative radiotherapy, by evaluating dietary intake prior to treatment (Study I), the psychometric properties of a new questionnaire on patient-reported gastrointestinal side effects (Study II), and the effect of a dietary intervention on acute and long-term gastrointestinal symptoms up to 2 years after radiotherapy completion (Study III-IV).Methods A total of 130 men with localized prostate cancer referred to dose-escalated radiotherapy (ED2 87-102 Gy, α/β=3 Gy) were recruited to a dietary intervention trial. READ MORE