Search for dissertations about: "Long noncoding RNAs"
Showing result 1 - 5 of 12 swedish dissertations containing the words Long noncoding RNAs.
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1. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach
Abstract : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. READ MORE
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2. Epigenetic Regulation by Noncoding RNA
Abstract : High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. READ MORE
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3. Regulatory roles for long noncoding RNAs and circular RNAs in human skin wound repair
Abstract : Human skin wound repair is a multiphase process, which includes inflammation, growth and remodeling, and requires the concerted communication of many cell types. During the course of healing, skin cells find themselves in a hostile environment where processes like migration, differentiation, apoptosis and proliferation must be correctly executed in order to restore the integrity of the injured tissue. READ MORE
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4. Cell cycle regulation in cancer: A noncoding perspective
Abstract : The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. READ MORE
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5. Molecular Insights into Kcnq1ot1 Noncoding Antisense RNA Mediated Long Range Transcriptional Gene Silencing
Abstract : Non-coding antisense RNAs have been implicated in the epigenetic silencing of individual gene as well as chromosomal domains. While silencing of the overlapping gene by antisense RNAs has been well investigated, their functional role in silencing of chromosomal domains remains enigmatic. READ MORE