Search for dissertations about: "Long-term depolarization"

Showing result 1 - 5 of 10 swedish dissertations containing the words Long-term depolarization.

  2. 1. Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line

    Author : Malin Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Prion; Scrapie; Voltage-gated N-type calcium channels; SNARE proteins; Exocytosis; Long-term depolarization;

    Abstract : The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs including dementia, ataxia and myoclonus. These diseases cause characteristic electroencephalographic changes. READ MORE

  4. 2. Metabolic aspects of cardiac arrhythmias

    Author : Sigfus Gizurarson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiologi; Electrofysiologi; Djurexperiment; Metabolism;

    Abstract : Cardiac arrhythmias are an important cause of mortality and morbidity in patients with cardiac diseases. Sudden death due to ventricular tachycardia and fibrillation (VT/VF) in the setting of acute myocardial infarction (AMI) and heart failure (HF) is a frequent cause of premature death. READ MORE

  5. 3. THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION

    Author : Helena Jones; Signaltransduktionsforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; PDE3B; exocytosis; insulin; diabetes; Medicine human and vertebrates ; Medicin människa och djur ; diabetologi; sekretion; Endokrinologi; diabetology; Endocrinology; secreting systems;

    Abstract : Type 2 diabetes mellitus (T2DM) is characterized by various combinations of ?-cell failure and insulin resistance leading to hyperglycemia and glucose intolerance. In order to maintain glucose tolerance in the insulin resistance state, increased insulin secretion is a requirement and it is because of inadequate islet adaptation that glucose intolerance develops in T2DM. READ MORE

  6. 4. Regulation of insulin secretion in diabetes: Molecular mechanism and applications

    Author : Rui Wu; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin production secretion; CaV channels; DEGs; aging; magnetic field;

    Abstract : Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. In this thesis, we aim to explore the underlying roles of CaV channels and aging-associated genetic changes in the development of Type 2 diabetes (T2D). READ MORE

  7. 5. The electrophysiological response of medial preoptic neurons to hypoxia and development of a system for patch-clamp measurement with full oxygen control

    Author : Nazanin Bitaraf; Ronnie Lundström; Luleå tekniska universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Medical Engineering for Healthcare; Medicinsk teknik för hälsovård;

    Abstract : A stroke is caused by interruption of the blood supply to the brain. Yearly 15 million people around the globe endure a stroke and the costs and suffering for the people involved and the society are immense. READ MORE