Search for dissertations about: "Ly49"

Showing result 1 - 5 of 16 swedish dissertations containing the word Ly49.

  2. 1. Diversity of CD1d-restricted natural killer T cells

    Author : Markus Sköld; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; autoreactive; Ly49 receptor; CD1d; NKT cell; transplantation; Immunologi; serologi;

    Abstract : The present study deals with natural killer (NK) T cells restricted to the antigen presenting molecule CD1d. NKT cells have been suggested to play a role in many diverse immunological situations such as clearance of different pathogens, protection against certain tumors, regulation of autoimmune reactions and as a link between innate and adaptive immune responses. READ MORE

  4. 2. Influence of Ly49 inhibitory receptors and MHC class I on T cell and NK cell function

    Author : Linda Öberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cell; T cell; Ly49; MHC class I;

    Abstract : Natural Killer cells (NK) can kill virus infected cells and tumor cells but do not harm normal surrounding cells. The function of Ly49 receptors on NK cells is important in maintaining selftolerance since they transmit inhibitory signals when bound to endogenous MHC class I molecules. Their role in T cells is however unclear. READ MORE

  5. 3. Natural killer cell tolerance : influence of the MHC class I expression in the host

    Author : Maria H Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; MHC class 1; tolerance; transgenic mice; Ly49;

    Abstract : Development of self-tolerance in the immune system is characterized by somatic processes aiming at permanently eliminating, or silencing, potentially autoreactive lymphocytes. Such tolerance mechanisms are of outmost importance if autoimmunity is to be avoided. READ MORE

  6. 4. Dynamics of MHC class 1 recognition by natural killer cells : from receptor modulation to ligand acquisition

    Author : Anna Sjöström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells are part of the innate immune system and can kill tumor cells and virus-infected cells without prior sensitization or clonal expansion. NK cells do not, in contrast to T and B cells, express any rearranged antigen-specific receptors. READ MORE

  7. 5. Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents

    Author : Jakob Michaëlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; MHC class 1; inhibitory receptors;

    Abstract : Natural Killer (NK) cells are an important part of the innate immune system. They can lyse target cells and secrete immunoregulatory cytokines early during immune responses. They mediate protection against viruses and tumours, and can reject MHC class I mismatched bone marrow grafts. READ MORE