Search for dissertations about: "Lysosomes"

Showing result 1 - 5 of 88 swedish dissertations containing the word Lysosomes.

  2. 1. Lysosomal Membrane Permeabilization : A Cellular Suicide Strategy

    Author : Ann-Charlotte Johansson; Karin Öllinger; Karin Roberg; Boris Zhivotovsky; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; lysosomes; lysosomal membrane permeabilization; cathepsins; Bax; Bid; mitochondria; caspases; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis signaling and execution has been achieved.The aim of this thesis was to clarify the role of lysosomal membrane permeabilization and lysosomal proteases, cathepsins, in signaling for apoptosis. READ MORE

  4. 2. Insulin-Producing Cells, Iron, Oxidative Stress, and Lysosomal Pathology

    Author : Beata Teresa Olejnicka; Enrique Cadenas; Linköpings universitet; []
    Keywords : Insulin-producing cells; redox-active iron; oxidative stress; lysosomes; desfenioxamine; MEDICINE; MEDICIN;

    Abstract : Accumulating evidence suggests that injnries caused by oxygen-derived radicals contribute to the destruction of pancreatic islet ß-cells in autoinnnune diabetes mellitus (diabetes type I, or IDDM). Oxidative stress may be caused by an enhanced production of oxygen-derived radicals, or by a decreased scavenging of such molecules. READ MORE

  5. 3. Mechanisms of lipofuscin/ceroid accumulation and its impact on the function of the lysosomal system

    Author : Alexei Terman; Thomas von Zglinicki; Linköpings universitet; []
    Keywords : Aging; Autophagocytosis; Centrophenoxine; Ceroid; Lipofuscin; Lysosomes; Oxidative stress; MEDICINE; MEDICIN;

    Abstract : The accumulation of lipofuscin - an electron-dense, autofluorescent, polymeric, intralysosomal substance - is a recognized hallmark of aging postmitotic cells. Ceroid- a substance very close, or perhaps even identical, to lipofuscin - is a characteristic of various pathological processes, such as lysosomal storage diseases, malnutrition, atherosclerosis, oxidative stress, ionizing radiation, etc. READ MORE

  6. 4. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease

    Author : Andrea Boman; Katarina Kågedal; Samuel Svensson; Alan Sabirsh; Per Svenningsson; Oskar Hansson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebrospinal fluid CSF ; biomarkers; therapeutic targets; neurodegeneration; Alzheimer’s disease AD ; Parkinson’s disease PD ; Corticobasal degeneration CBD ; Progressive supraneuclear palsy PSP ; Lysosomes; Endosomes; Autophagy; LAMP-2; Lysozyme;

    Abstract : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. READ MORE

  7. 5. Lysosomes and pancreatic islet function

    Author : Annika Schnell Landström; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE