Search for dissertations about: "MAIT cells"

Showing result 1 - 5 of 20 swedish dissertations containing the words MAIT cells.

  1. 1. Bacterial Regulation of Peripheral Immunity : Mechanistic insights from lactobacilli and Staphylococcus aureus

    Author : Manuel Mata Forsberg; Eva Sverremark-Ekström; Monika Brunner-Weinzierl; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; Immune regulation; Cytokines; T cells; gamma-delta T cells; MAIT cells; NK cells; Lactobacillus; Staphylococcus aureus; staphylococcal enterotoxins; molekylär biovetenskap; Molecular Bioscience;

    Abstract : There is a constant cross-talk between our immune system and the colonizing microbiota. The gut resident bacteria produce a broad range of molecules with regulatory activities in both local and distal tissues. Staphylococcus (S. READ MORE

  2. 2. Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function

    Author : Filip Ahlmanner; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colon cancer; regulatory T cells; CD39; adenosine; immune checkpoint molecules; immunosuppression; MAIT cells; cytokines; cancer-specific survival;

    Abstract : In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the balance between these two counteracting forces partly determines patient outcome. READ MORE

  3. 3. The antimicrobial role of human MAIT cells

    Author : Caroline Boulouis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : MAIT cells are unconventional T cells that have characteristics of both innate and adaptive immunity. Their fast mobilization and wide distribution in tissues make them part of the first line of defense against infection. MAIT cells recognize riboflavin-related metabolites produced by bacteria and presented by MR1. READ MORE

  4. 4. Role of MAIT cells in human antimicrobial immunity

    Author : Joana Dias; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mucosa-associated invariant T (MAIT) cells are a relatively recently discovered subset of unconventional T cells. In humans, MAIT cells are predominantly CD8+CD4- (CD8+) with a smaller CD8-CD4- (double-negative, DN) subset, and they are abundant in the peripheral blood, liver, and mucosal tissues. READ MORE

  5. 5. Potential role of MAIT cells in cancer immunotherapy and viral infection

    Author : Katie Healy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mucosa-associated invariant T (MAIT) cells are an unconventional T cell subset with specialized antimicrobial functions. In humans, MAIT cells are characterized by their effector memory phenotype, rapid cytolytic capacity, and tissue-homing properties. READ MORE