Search for dissertations about: "MAO-B"

Showing result 1 - 5 of 13 swedish dissertations containing the word MAO-B.

2. 1. The Relation between Serotonergic Biomarkers and Behaviour : – studies on human primates, non-human primates and transgenic mice

   Author : Hanna-Linn Wargelius; Dan Larhammar; Lars Oreland; Claudia Fahlke; Elias Eriksson; Uppsala universitet; []
   Keywords : Serotonin; MAO-A; 5-HTT; MAO-B; alcohol; ADHD; MEDICINE; MEDICIN; Medicin; Medicine; Neuroscience; Neurovetenskap;

   Abstract : Rationale: The serotonergic system is involved in the modulation of emotion and plays an important role for personality and vulnerability for psychiatric disorders. In the papers included in this thesis, we investigate three biological factors that have been studied in relation to psychiatric symptoms: Platelet monoamine oxidase B (MAO-B) activity, and variations in the MAO-A and the serotonin transporter (5HTT) genes. READ MORE

4. 2. Serotonergic aspects on high consumption of alcohol in humans. Experimental and clinical studies

   Author : Matts Eriksson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol; alcohol-dependence; serotonin; SSRI; MAO-B; DRD2 A1 A2 alleles; fenfluramine; mood;

   Abstract : In animal studies an association between alcohol intake and central serotonergic function has been demonstrated. There are also evidence for altered serotonergic neurotransmission in subgroups of alcohol-dependent subjects. READ MORE

5. 3. Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B)

   Author : Sangram Nag; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the treatment of psychiatric and neurological disorders. READ MORE

6. 4. Attention-deficit/hyperactivity disorder and disruptive behavior disorders in adolescence related to levels of platelet MAO-B and polymorphisms in two candidate genes

   Author : Kerstin Malmberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : MAO-A;

   Abstract : Background: Attention-Deficit/Hyperactivity Disorder (ADHD) and Disruptive Behavior Disorders (DBD) (including Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD)), are common developmental and behaviour diagnoses among adolescents. Several of their symptoms, have been linked to genotypes (e.g. READ MORE

7. 5. Isotopes as Mechanism Spies : Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects

   Author : Susanna MacMillar; Olle Matsson; Anita Hussénius; Daniel M. Quinn; Uppsala universitet; []
   Keywords : Organic chemistry; nucleophilic bimolecular substitution SN2; kinetic isotope effects; precision conductometry; monoamine oxidase B MAO B; reaction mechanism; carbon 11C 14C kinetic isotope effect; ion pairing triple-ion formation; para-substituted benzyl chlorides; tetrabytylammonium cyanide; Organisk kemi;

   Abstract : This thesis concerns the study of reaction mechanisms by means of kinetic isotope effects (KIEs). Studies of the nucleophilic bimolecular substitution (SN2) reaction had the dual purpose of improving our fundamental understanding of molecular reactivity and assessing the ability of kinetic isotope effects to serve as mechanistic tools. READ MORE