Search for dissertations about: "MAPKs"
Showing result 1 - 5 of 18 swedish dissertations containing the word MAPKs.
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1. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1
Abstract : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. READ MORE
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2. Host cell responses to Helicobacter pylori secreted factors
Abstract : The infection of the human gastric mucosa by the bacterium Helicobacter pylori can lead to the development of gastritis, gastroduodenal ulcers, and cancer. The factors that determine disease development in a small percentage of infected individuals are still not fully understood. READ MORE
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3. Glucose, Palmitate and Apolipoprotein CIII-induced Effects on Insulin-Producing β-cells
Abstract : Background and aims: Type 2 diabetes mellitus results from complex interplay between genetic predisposition and environmental factors that together promote impairment of insulin-producing β-cells. Elevated levels of glucose, fatty acid palmitate and apolipoprotein CIII (apoCIII) are implicated in this process. READ MORE
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4. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death
Abstract : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. READ MORE
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5. The role of glucocorticoid receptors and mitogen-regulated protein kinases in the cochlea
Abstract : Hearing loss induced by acoustic trauma is a common handicap for the human population. Acoustic trauma triggers a cascade of changes in the cochlea such as a direct mechanical damage of sensory hair cells, biochemical disturbances including reactive oxygen and nitrogen species generation, release of pro-inflammatory cytokines and exitotoxicity. READ MORE