Search for dissertations about: "MCF-7"

Showing result 1 - 5 of 35 swedish dissertations containing the word MCF-7.

  2. 1. Effects of polyamine pool manipulation on genes expressed during the cell cycle

    Author : Pia Berntsson; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Animal physiology; cyclin A; ODC; MCF-7; mitotic shake off; DENSPM; CHO; cDNA microarray; cell cycle; spermine; Djurfysiologi; AdoMetDC; 2D gel electrophoresis; polyamines; spermidine; putrescine;

    Abstract : The polyamines - putrescine, spermidine and spermine - are polycations found within cells. They have been shown to be essential for optimal cell proliferation and cell survival. Cells maintain their polyamine levels in a well-regulated system involving biosynthesis, catabolism and uptake/excretion. READ MORE

  4. 2. Effects of sex steroids and tamoxifen on VEGF in the breast

    Author : Stina Garvin; Charlotta Dabrosin; Lars Holmgren; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; breast cancer; estradiol; MCF-7; microdialysis; nude mice; progesterone; sVEGFR-1; VEGFR-2; Oncology; Onkologi;

    Abstract : Sex steroid exposure constitutes a risk factor for breast cancer, but little is known about the effects of sex steroids on factors mediating angiogenesis, the development of new blood vessels, in normal and malignant breast tissue. In this thesis we have investigated the effects of estradiol, progesterone, and the nonsteroidal anti-estrogen tamoxifen on vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 and VEGFR-2) in normal human breast tissue, endothelial cells, and breast cancer. READ MORE

  5. 3. Effects of sex steroids and tamoxifen on matrix metalloproteinase activity and generation of endostatin in the breast

    Author : Ulrika W. Nilsson; Charlotta Dabrosin; Lena Claesson-Welsh; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Breast cancer; TGF-β1; Endostatin; Estradiol; Mammary gland; Matrix metalloproteinases; MCF-7; Microdialysis; Nude mice; Tamoxifen; Oncology; Onkologi;

    Abstract : Sex steroids are inevitable in women. However, long-term exposure to sex steroids increases the risk of breast cancer. A complete understanding of sex steroid control of the breast and how it relates to breast cancer risk is still lacking. READ MORE

  6. 4. Hypothermia and radiation. Effects on DNA, chromatin and cellular survival

    Author : Kerstin Elmroth; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cells; temperature; irradiation; dsb; survival; fluorescent nucleoid assay; hypothermia;

    Abstract : The effect of ionising radiation on cells can be modulated by several physico-chemical factors. The aim of this study was to investigate if hypothermic (sub-physiological) temperatures (2°C-28°C) may influence the effect of X-rays on cellular damage in human normal fibroblasts and in a human breast adenocarcinoma cell line, MCF-7. READ MORE

  7. 5. Role of DARPP-32 in Breast Cancer Cell Signalling and Migration

    Author : Christian Hansen; Molekylär neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell migration; protein phosphatase 1.; DARPP-32; breast cancer; protein kinase A;

    Abstract : Breast cancer is the most common form of cancer in women. While the prognosis for breast cancer patients without local or distal dissemination is relatively favorable, the prognosis is considerably worse once distal metastasis has been established. READ MORE