Search for dissertations about: "MCM3"

Found 4 swedish dissertations containing the word MCM3.

  2. 1. The role of RNA-binding motif 3 in epithelial ovarian cancer: A biomarker discovery approach

    Author : Åsa Ehlén; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA integrity checkpoint; cisplatin treatment; prognostic predictive marker; RBM3; epithelial ovarian cancer; Chk1; Chk2; MCM3;

    Abstract : Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies and there is an urgent need to develop new prognostic and treatment predictive biomarkers for a more efficient therapy. The discovery of the RNA-binding motif protein 3 (RBM3) as a putative cancer biomarker was based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). READ MORE

  4. 2. Immunohistochemical and molecular studies on ovarian cancer progression and prognosis

    Author : Björn Nodin; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epithelial ovarian cancer; prognostic and predictive biomarkers; tissue microarrays; androgen receptor; RBM3; Chek1; Chek2; MCM3; Dachshund 2; SATB1; KRAS mutation;

    Abstract : Epithelial ovarian cancer (EOC) is the most lethal malignancy of the female reproductive tract. Due to vague symptomatology, the majority of EOC patients are diagnosed in advanced clinical stages with poor survival rates, despite improvements in surgical techniques and the advent of targeted therapeutics. READ MORE

  5. 3. Modulation of nuclear receptor function by interacting proteins

    Author : Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. READ MORE

  6. 4. Mammalian cell cycle regulation : characterisation of three genes expressed in proliferating cells

    Author : Maria Starborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cell cycle; DNA replication; licensing factor; mitosis; ceheckpoint regulator; centromere regions; cell proliferation marker; nucleolar protein; spermatogenesis;

    Abstract : Proliferating cells undergo different phases in their life cycle. During interphase the cells grow and duplicate their DNA content, followed by a cell division phase, mitosis, which results in two daughter cells. READ MORE