Search for dissertations about: "MDL 201"

Found 3 swedish dissertations containing the words MDL 201.

  1. 1. Islet xenotransplantation : An immunological study in the pig-to-mouse model

    Author : Birgitta Benda; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; xenotransplantation; porcine; islet; in vivo; knock-out mouse; immunohistochemistry; CsA; MDL 201; 449A; Ig; FcR; IL-6; perforin; granzyme B; macrophage; eosinophilic granulocyte; T cell; TCR; IFN- g; TNF- a; IL-2; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

    Abstract : Successful clinical xenotransplantation, i.e., transplantation between species, would eliminate the shortage of donor organs. In order to study the acute cellular rejection reaction following discordant xenogeneic transplantation, an experimental pig-to- mouse islet xenotransplantation model was established. READ MORE

  2. 2. Prevention of type 1 diabetes mellitus in experimental studies

    Author : Maria Holstad; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cytokines; inducible nitric oxide synthase; nitric oxide; NOD mice; pancreatic islets; prolactin; syngeneic islet transplantation; tumour necrosis factor alpha; type 1 diabetes mellitus; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The aim of the study was to examine the immune response and different immunoprotective strategies in experimental type 1 diabetes mellitus. The autoimmune destruction of the insulin-producing pancreatic β-cells that leads to type 1 diabetes is complex and incompletely understood. READ MORE

  3. 3. Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus

    Author : Lina Thorvaldson; Stellan Sandler; Michael Welsh; Maria Holstad; Maria Faresjö; Uppsala universitet; []
    Keywords : Cell biology; Cytokine; Diabetes; Tumor necrosis factor-α; Interferon-γ; Interleukin-4; Interleukin-10; Transplantation; Pancreatic islet; Glucose; Regulatory T cell; Cellbiologi;

    Abstract : Cytokines are soluble signalling mediators within the immune system, and have been shown to be of importance in the development of type 1 diabetes (T1D). This thesis studied the production of cytokines in experimental models of T1D and during transplantation of insulin-producing islets of Langerhans. READ MORE