Search for dissertations about: "MDM2 p53 interaction"

Showing result 1 - 5 of 14 swedish dissertations containing the words MDM2 p53 interaction.

2. 1. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors

   Author : Mariell Pettersson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interactionProtein-protein interaction; MDM2 p53 interaction; MDM2 inhibitors; α- helix mimetics; β-hairpin; 2; 5-diketopiperazine; spiro-2; 5-diketopiperazine; purine; 8- triazolyl purine; solution conformational analysis; NAMFIS; fluorescence;

   Abstract : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. READ MORE

4. 2. Evolution of Interactions Involving Intrinsically Disordered Proteins

   Author : Emma Åberg; Per Jemth; Madan Babu; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered proteins; protein evolution; phylogenetics; ancestral sequence reconstruction; biophysical characterization; NCBD; CID; p53; MDM2; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Biokemi; Biochemistry;

   Abstract : This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of phylogenetic analysis, ancestral reconstruction and biophysical characterization in order to examine the evolutionary trajectory of protein-protein interactions involving disorder. READ MORE

5. 3. Pharmacological targeting of p53 pathway alterations in tumors

   Author : Ying Zhao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The p53 tumor suppressor plays an important role in cell fate decisions upon diverse stress conditions. In response to stress, p53 functions as a transcription factor, activating transcription of a variety of its target genes responsible for several cellular responses, most importantly cell cycle arrest and apoptosis. READ MORE

6. 4. p53 reactivation by the small molecule RITA : molecular mechanisms

   Author : Vera Grinkevich; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Inactivation of the tumor suppressor p53 is essential for the development and maintenance of cancer cells. Therefore, reactivation of p53 appears to be a promising strategy for anti-cancer therapy. READ MORE

7. 5. Molecular mechanisms of growth suppression by pharmacologically activated p53

   Author : Elisabeth Hedström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The tumor suppressor p53 is a transcription factor that is crucial for protecting cells from cancer development. The importance of p53 tumor suppression function is highlighted by the fact that the p53 pathway is inactivated in most, if not all cancers. READ MORE