Search for dissertations about: "MEDICIN Kemi Neurokemi"

Showing result 16 - 20 of 39 swedish dissertations containing the words MEDICIN Kemi Neurokemi.

  1. 16. Cell-penetrating peptides in cargo delivery : In vitro studies on uptake and in vivo studies on tumor targeting

    University dissertation from Stockholm : Institutionen för neurokemi

    Author : Helena Myrberg; Stockholms universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The capability of cell-penetrating peptides (CPPs) to transport cargos over different cellular membranes both in vitro and in vivo have drawn major attention in the past decade. Three main topics on the application of CPPs have been studied in this thesis. READ MORE

  2. 17. Rational modifications of cell-penetrating peptides for drug delivery Applications in tumor targeting and oligonucleotide delivery

    University dissertation from Stockholm : Institutionen för neurokemi

    Author : Maarja Mäe; Stockholms universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptide; oligonucleotide; drug delivery; tumor targeting; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : High molecular weight biomolecules are becoming important in the development of new therapeutics. However, their size and nature creates a major limitation for their application – poor penetration through biological membranes. READ MORE

  3. 18. Oxidative mechanisms in London Familial Alzheimer´s disease and LPS-induced inflammation

    University dissertation from Stockholm : Institutionen för neurokemi

    Author : Katarina Reis; Stockholms universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Alzheimer´s disease (AD) is the most common of the progressive neurodegenerative disorders and is characterized by the formation of Aβ deposits, neurofibrillary tangles and loss of neurons. Additional features of the disease are inflammation, increased oxidative stress and modified iron metabolism. READ MORE

  4. 19. Temporal events in neuronal differentiation and cell death : expression and processing of the Alzheimer's amyloid precursor protein family and a protein at the nuclear pore

    University dissertation from Stockholm : Dep. of Neurochemistry, Stockholm University

    Author : Marie Beckman; Stockholms universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Abstract : The present study had two major objectives: 1) to elucidate the involvement of Alzheimer’s amyloid precursor protein (APP) family in neuronal differentiation, and the effect of the Alzheimer’s disease (AD)-linked mutation APPV642I on signal transduction; 2) to investigate the fate of the nuclear pore complex protein POM121 during apoptosis and to examine the possibility of using green fluorescent protein (GFP)-labelled POM121 as a non-invasive sensor of apoptosis in living (non-fixed) cells.APP is the parent protein of the b-amyloid peptide, which is the major peptide constituent in the “senile plaques” of AD. READ MORE

  5. 20. Characterization of galanin receptors using chimeric peptides and site-directed mutagenesis

    University dissertation from Stockholm : Department of Neurochemistry, Stockholm University

    Author : Ulla Eriksson Sollenberg; Stockholms universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galanin; GPCR; mutagenesis; neuropeptide; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Abstract : Galanin, a 29 (30) amino acid neuropeptide, is found throughout both the central and peripheral nervous systems. It signals via three receptors, GalR1-3, all belonging to the rhodopsin-like G-protein coupled receptors. Galanin and its receptors have been implicated in a vast variety of biological processes. READ MORE