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Showing result 1 - 5 of 129 swedish dissertations matching the above criteria.

2. 1. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells

   Author : Oskar Hemmingsson; Peter Naredi; Mef Nilbert; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; Surgery; Kirurgi; Oncology; Onkologi; Surgery; kirurgi; Oncology; onkologi; cellforskning; cell research;

   Abstract : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. READ MORE

4. 2. Tumour stromal and demographical factors affecting the metastatic aggressiveness of small differentiated papillary thyroid cancers in Sweden

   Author : Haytham Bayadsi; Joakim Hennings; Malin Sund; Robert Bränström; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Papillary thyroid cancer; Tumour stroma; Geographic information system; Register; Surgery; kirurgi;

   Abstract : Background: The incidence of papillary thyroid cancer (PTC) has been increasing over the recent decades, especially that of small papillary thyroid cancers (sPTCs) (≤ 20mm in size). sPTCs are generally classified as low risk cancers with a very favourable diagnosis, yet some of these cancers still cause locoregional and distant metastasis, recurrence and even death. READ MORE

5. 3. Stromal components and micro-RNAs as biomarkers in pancreatic cancer

   Author : Oskar Franklin; Malin Sund; Daniel Öhlund; Ola Billing; Marco Del Chiaro; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; stroma; basement membrane; tumour markers; type IV collagen; endostatin; osteopontin; tenascin c; hyaluronan; CD44; micro-RNA; kirurgi; Surgery;

   Abstract : Background Pancreatic ductal adenocarcinoma (PDAC) patients have the poorest 5-year survival rates of all cancer forms. It is difficult to diagnose at early disease stages, tumour relapse after surgery is common, and current chemotherapies are ineffective. READ MORE

6. 4. The role of stroma-derived substances in breast cancer progression and their function as tumour markers

   Author : Malin Jansson; Malin Sund; Daniel Öhlund; Ola Billing; Emma Niméus; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; perlecan; type IV collagen; type I collagen; extracellular matrix; tumour biomarkers; Surgery; kirurgi;

   Abstract : Background: In 2020, more than 2,260,000 women were diagnosed with breast cancer. Most patients are cured with surgery and adjuvant treatment, but despite that, approximately 700,000 women die of the disease every year. The historical focus on breast cancer progression has been on the malignant epithelial cell. READ MORE

7. 5. HIPECology : Aspects of Postoperative Morbidity Following the HIPEC Procedure

   Author : Paul Dranichnikov; Peter Cashin; Wilhelm Graf; Martin Rutegård; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CRS; HIPEC; readmission; EPIC; coagulopathy; VTE; goal-directed therapy GDT ; postoperative hemorrhage; oxaliplatin.; Surgery; Kirurgi; Oncology; Onkologi;

   Abstract : Peritoneal surface malignancy (PM), regardless of the dissemination site, was once considered a terminal condition.  However, the introduction of a surgical approach with cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) with or without early intraperitoneal chemotherapy (EPIC) shifted the attitude from managing the symptoms of PM to disease treatment with curative intent. READ MORE