Search for dissertations about: "MEMBRANE-PROTEIN"

Showing result 1 - 5 of 293 swedish dissertations containing the word MEMBRANE-PROTEIN.

  1. 1. Membrane protein topogenesis

    Author : Karin Öjemalm; Gunnar von Heijne; Tracy Palmer; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Abstract : The membranes of cells are highly complex and heterogeneous structures that fulfill multiple vital tasks. They form thin barriers that seal out the environment, thus defining the cell’s boundaries. READ MORE

  2. 2. Membrane Protein Biogenesis in Escherichia coli : A proteomics approach

    Author : David Vikström; Jan-Willem de Gier; Eitan Bibi; Stockholms universitet; []
    Keywords : SRP; YidC; SecE; Membrane protein biogenesis; protein targeting; 2D BN SDS-PAGE; biokemi; Biochemistry;

    Abstract : In the bacterium Escherichia coli all proteins are synthesized in the cytoplasm. However, at least 25% of them then need to be exported to another cellular compartment where they exert their function. E. coli has several different targeting pathways to ensure the correct localization of its proteins. READ MORE

  3. 3. Sequence-based predictions of membrane-protein topology, homology and insertion

    Author : Andreas Bernsel; Gunnar von Heijne; Volkhard Helms; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; membrane protein; topology prediction; hidden markov model; homology detection; Sec translocon; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

    Abstract : Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide variety of biochemical pathways. Apart from their general biological significance, membrane proteins are of particular interest to the pharmaceutical industry, being targets for more than half of all available drugs. READ MORE

  4. 4. Determinants of membrane protein topology

    Author : Marie Johansson; Collin Robinson; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Abstract : The living cell, no matter if it is a simple prokaryotic bacterial cell or a highly specialised eukaryotic cell, synthesises a vast number of different proteins. In most organisms, 20-30 % of all proteins are thought to be transmembrane integral membrane proteins. READ MORE

  5. 5. Intracellular vesicles induced by monotopic membrane protein in Escherichia coli

    Author : Hanna M. Eriksson; Åke Wieslander; Meta Kuehn; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Membrane protein; intracellular vesicles; Escherichia coli; glycosyltransferase; overexpression; optimization; detergent; screening; lipid composition; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : The monotopic membrane protein alMGS, a glycosyltransferase catalyzing glucolipid synthesis in Acholeplasma laidlawii, was overexpressed in Escherichia coli. Optimization of basic growth parameters was performed, and a novel method for detergent and buffer screening using a small size-exclusion chromatography was developed. READ MORE