Search for dissertations about: "MEP"

Showing result 1 - 5 of 16 swedish dissertations containing the word MEP.

  2. 1. Enzymes in the Mycobacterium tuberculosis MEP and CoA Pathways Targeted for Structure-Based Drug Design

    Author : Christofer Björkelid; T. Alwyn Jones; Torsten Unge; Sherry L. Mowbray; William N. Hunter; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Tuberculosis; Mycobacterium tuberculosis; MEP pathway; CoA pathway; drug development; crystal structure; DXR; IspD; PanK; Biokemi; Biochemistry; Molecular Biology; Molekylärbiologi;

    Abstract : Tuberculosis, caused by the pathogenic bacteria Mycobacterium tuberculosis, is one of the most widespread and deadly infectious diseases today. Treatment of tuberculosis relies on antibiotics that were developed more than 50 years ago. These are now becoming ineffective due to the emergence of antibiotic resistant strains of the bacteria. READ MORE

  4. 2. Novel Synthetic Biology Tools for Metabolic Engineering of Saccharomyces cerevisiae

    Author : Siavash Partow; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yeast promoter; MVA pathway; Metabolic engineering; Multi-copy plasmid.; Synthetic biology; S. cerevisiae; MEP pathway;

    Abstract : The most well characterized eukaryote model organism Saccharomyces cerevisiae is not only preferred as a microbial cell factory for synthesis of industrial products, e.g. bioethanol, but this eukaryote host system is also defined as a robust scaffold for commercial production of diverse chemicals e.g. READ MORE

  5. 3. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

    Author : Anna M. Jansson; T. Alwyn Jones; Sherry L. Mowbray; E. Yvonne Jones; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. READ MORE

  6. 4. Structural and Functional Studies of Peptidyl-prolyl cis-trans isomerase A and 1-deoxy-D-xylulose- 5-phosphate reductoisomerase from Mycobacterium tuberculosis

    Author : Lena M Henriksson; Torsten Unge; Sherry L. Mowbray; Barbara Seaton; Uppsala universitet; []
    Keywords : Molecular biology; Mycobacterium tuberculosis; Rv0009; peptidyl-prolyl cis-trans isomerase; Rv2870c; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; non-mevalonate pathway; DOXP MEP pathway; X-ray crystallography; Molekylärbiologi;

    Abstract : Mycobacterium tuberculosis, the causative pathogen of tuberculosis, currently infects one-third of the world’s population, resulting in two million deaths annually. This clearly shows that tuberculosis is one of the most serious diseases of our times. READ MORE

  7. 5. Dynamical Analysis of Chemical Activity of Sterically Encumbered Lewis acid/base Pairs

    Author : Maoping Pu; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This licentiate thesis is about the dynamics analysis of chemical reactions involving a stoichiometric mixture of sterically hindered Lewis base (LB) and Lewis acid (LA) – the so-called frustrated Lewis pairs (FLPs). The tool for dynamical description of chemical reactions is the ab initio molecular dynamics (AIMD) simulations together with the calculation of minimum energy paths (MEPs) on the potential energy surfaces (PESs). READ MORE