Search for dissertations about: "MHC class 1"

Showing result 21 - 25 of 159 swedish dissertations containing the words MHC class 1.

  2. 21. B cell deviations and type 1 diabetes in the NOD mouse

    Author : Mia Sundström; Kristina Lejon; Susanna Cardell; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Type 1 diabetes; Autoimmunity; NOD mouse; Idd; TACI; Immune response; Immune complex; immunologi; Immunology;

    Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease in which the insulin producing β-cells in the pancreatic islets of Langerhans are selectively attacked by the immune system. The β-cells are destroyed resulting in a reduced or eliminated insulin production, which in turn lead to a high blood glucose level. READ MORE

  4. 22. Processing of live and heat inactivated Sendai virus for presentation on MHC class I molecules

    Author : Tianmin Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : antigen presentation; antigen processing; APC; CTL; MHC class1; peptides; Sendai virus; TAP;

    Abstract : The present thesis deals with processing of antigens from live and heat inactivated Sendai virus and their loading on MHC class I molecules for presentation to CTL. In paper I it was observed surprisingly that T2 cells (T2 cells transfected with H-2Kb), being defective in the expression of TAP peptide transporters, still presented Sendai virus antigen on MHC class I molecules to CTL. READ MORE

  5. 23. Genetic analysis of candidate susceptibility genes for type 1 diabetes

    Author : Samina Asad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Type 1 diabetes (T1D) is a complex disease where the pancreatic β-cells are destroyed in an autoimmune attack. For the patients, this leads to lifelong daily insulin treatment and increased risk for various kinds of complications. It is thought that both environmental as well as genetic factors act in concert to cause T1D. READ MORE

  6. 24. Immunogenetics of Type 1 diabetes and Celiac disease

    Author : Shehab Abdulaziz Alshiekh; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiac disease; type 1 diabetes; children; genetics; human leukocyte antigen; next generation sequencing;

    Abstract : AbstractThe primary purpose of understanding disease etiology is to explain how a specific phenotype is determined by genotype. In pursue of this aim, exploring the diversity in DNA sequence variants that affect biomedical traits, especially those related to the onset and progression of genetically determined human disease. READ MORE

  7. 25. Interplay between superantigens and immunoreceptors

    Author : Karin Lindkvist; Medicinsk strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; serology; Immunology; TCR; MHC class II; X-ray crystallography; superantigen; staphylococcal enterotoxin; Biofysik; transplantation; Immunologi; serologi; Biophysics;

    Abstract : This thesis deals with the interactions between superantigens and their receptors. Superantigens are proteins that are secreted by various bacteria, such as Staphylococcus aureus and Streptococcus pyogenes. Superantigens are able to cross-link T cells and antigen presenting cells by binding to the T cell receptor (TCR) and MHC class II. READ MORE