Search for dissertations about: "MHC class I"
Showing result 16 - 20 of 197 swedish dissertations containing the words MHC class I.
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16. Influence of Ly49 inhibitory receptors and MHC class I on T cell and NK cell function
Abstract : Natural Killer cells (NK) can kill virus infected cells and tumor cells but do not harm normal surrounding cells. The function of Ly49 receptors on NK cells is important in maintaining selftolerance since they transmit inhibitory signals when bound to endogenous MHC class I molecules. Their role in T cells is however unclear. READ MORE
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17. Studies of cytotoxic T lymphocytes and natural killer cells in relation to MHC class I presented peptides
Abstract : In the defense against disease it is essential for the immune system to be able to discriminate self/normal from non-self/abnormal. This key feature of the immune system relies on the presentation of antigens by MHC class I and class II molecules. READ MORE
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18. Genetic Variation in Mhc Class II B in Atlantic Salmon: Evolutionary and Ecological Perspectives
Abstract : The Major Histocompatibility Complex (Mhc) genes are crucial for the recognition of self and non-self peptides by the immune defence system. They are extremely variable in most studied vertebrate species. I have studied the extent and the importance of Mhc variation in Atlantic salmon (Salmo salar), mainly from the Baltic Sea. READ MORE
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19. Evolution of MHC Genes and MHC Gene Expression
Abstract : Polymorphism in coding regions and regions controlling gene expression is the major determinant of adaptive differences in natural populations. Genes of the major histocompatibility complex (MHC) possess a high level of genetic variation, which is maintained by selection over long coalescence times. READ MORE
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20. Influence of MHC class I peptide interaction on antigen presentation in normal and malignant cells
Abstract : The presentation of MHC class I peptide complexes in normal and malignant cells was studied. An HLA A11 binding motif was defined by comparing synthetic peptide analogues of a known cytotoxic T Iymphocyte (CTL) target epitope for induction of surface A11 expression and triggering of cytotoxic activity. READ MORE