Search for dissertations about: "MHC class I"

Showing result 21 - 25 of 197 swedish dissertations containing the words MHC class I.

  2. 21. MHC and genomic diversity in Atlantic salmon (Salmo salar L.)

    Author : Jakob Lohm; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Djurekologi; cytogenetik; Genetik; cytogenetics; Genetics; nucleotide diversity; isolation-by-distance; DGGE; AFLP; furunculosis; disease resistance; Arctic charr; brown trout; Atlantic salmon; population genetics; genetic variation; Mhc class IIB; Animal ecology;

    Abstract : In this thesis I present studies concerning genomic diversity and genetic heterogeneity as well as the evolution and maintenance of genetic variation at a specific immune defence gene in Atlantic salmon (Salmo salar, L.). READ MORE

  4. 22. Structural studies of MHC class 1 complexes : implications for NK- and T-cell recognition

    Author : Adnane Achour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Crystallography; MHC class I molecules; MHC class I tetramers; NK cells; T cells;

    Abstract : The cell-cell recognition events and the functional characteristics of the cell surface receptors that govern the responses of NK- and T-cells are central to molecular immunology. This thesis addresses the structural basis of such molecular recognition, more specifically the interaction between peptides and MHC class I molecules, as well as the interaction between such complexes and the inhibitory Ly49 receptors of NK cells or triggering antigen specific receptors of T-cells (TCR). READ MORE

  5. 23. Mapping of the specificity in MHC class I recognition by natural killer cells

    Author : Margareta Waldenström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells represent the third major lymphocyte subpopulation. They are distinguishable from B and T lymphocytes by their surface phenotype, cytokine profile and the ability to mediate spontaneous cytotoxicity, without prior sensitization, against certain tumor cells and virally infected cells. READ MORE

  6. 24. MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells

    Author : Adil Doganay Duru; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats by scanning a repertoire of peptide epitopes presented by major histocompatibility complex (MHC) molecules. READ MORE

  7. 25. Processing of live and heat inactivated Sendai virus for presentation on MHC class I molecules

    Author : Tianmin Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : antigen presentation; antigen processing; APC; CTL; MHC class1; peptides; Sendai virus; TAP;

    Abstract : The present thesis deals with processing of antigens from live and heat inactivated Sendai virus and their loading on MHC class I molecules for presentation to CTL. In paper I it was observed surprisingly that T2 cells (T2 cells transfected with H-2Kb), being defective in the expression of TAP peptide transporters, still presented Sendai virus antigen on MHC class I molecules to CTL. READ MORE