Search for dissertations about: "MHC region"
Showing result 1 - 5 of 68 swedish dissertations containing the words MHC region.
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1. Evolution of MHC Genes and MHC Gene Expression
Abstract : Polymorphism in coding regions and regions controlling gene expression is the major determinant of adaptive differences in natural populations. Genes of the major histocompatibility complex (MHC) possess a high level of genetic variation, which is maintained by selection over long coalescence times. READ MORE
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2. MHC diversity and expression in a songbird : Temporal and transgenerational variation
Abstract : The immune system is of central importance to clear-off pathogens in order to keep an organism healthy. In vertebrates, the Major Histocompatibility Complex (MHC) is a genomic region that holds key genes involved in adaptive immunity and in particular in the antigen presenting process. READ MORE
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3. Analysis of genetic susceptibility to cervical cancer using candidate gene and GWAS approaches
Abstract : Cervical cancer is the forth most commonly diagnosed cancer among women worldwide. It is caused by persistent infection with an oncogenic type of Human Papillomavirus (HPV). The HPV is a necessary but not sufficient cause of cervical cancer. READ MORE
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4. Immunological and Inflammtory Responses against Intrastriatal Neural Grafts in the Rat
Abstract : Intracerebral neural transplantation offers a new strategy to combat Parkinson’s and Huntington’s diseases. However, a host immune response against a histoincompatible neural graft in the brain may jeopardize transplant survival. READ MORE
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5. Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat
Abstract : The major histocompatibility complex (MHC) is an allele-rich and exceptionally gene dense region on human chromosome 6. Over 40% of the genes in this region have immune-related functions, including genes encoding MHCI and MHCII molecules. These molecules, which are found in nearly all vertebrates, present antigenic peptides to CD4 and CD8 T cells. READ MORE