Search for dissertations about: "MHC-I"

Showing result 1 - 5 of 26 swedish dissertations containing the word MHC-I.

  1. 1. The MHC genes: variation and impact on life-history traits in house sparrwos

    University dissertation from Department of Biology, Lund University

    Author : Maria Karlsson; Lund University.; Lunds universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MHC-I; house sparrow; 454-amplicon sequencing; cDNA; functional clustering; trans-species evolution; nestling survival; mate-choice;

    Abstract : In birds the major histocompatibility complex (MHC) organization differs both among and within orders. Galliformes often have simple arrangements with few transcribed MHC genes whilst many songbirds (Passeriformes) have a complex arrangement with many MHC genes and also presence of pseudo-genes. READ MORE

  2. 2. Avian MHC : Characterization and expression patterns of classical and non-classical MHC-I genes

    University dissertation from Department of Biology, Lund University

    Author : Anna Drews; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018-10-29]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MCH class I; Classical genes; Non-classical genes; Expression; Passerine birds;

    Abstract : The function of the vertebrate immune system is to enable recognition and elimination of microorganisms that can cause harm (pathogens). A key component in adaptive immunity is the major histocompatibility complex (MHC) that codes for molecules with antigen presentation function. READ MORE

  3. 3. Natural killer cell education under conditions of perturbed sensing of MHC : studies in MHC-I mosaic and chimaeric mice

    University dissertation from Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Author : Sadia Salam; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Natural killer (NK) cells are innate lymphocytes that play a role in infections, tumours and transplantation. Their activating and inhibitory receptors sense cell surface ligands on potential target cells. READ MORE

  4. 4. Processing and presentation of exogenous antigen by dendritic cells

    University dissertation from Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Author : Liying Chen; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DC; vesicular MHC-I processing; Adenosine; CD 1 d; TACA;

    Abstract : Dendritic cells (DC) play a key role in the immune system. In this thesis, we have investigated and characterized pathways for the processing and presentation of exogenous OVA on MHC-I ("cross-presentation") and how these were influenced by the purine nucleoside Adenosine (Ado), an immune regulator that accumulates to high concentrations at sites of inflammation and tumor growth. READ MORE

  5. 5. MHC class I - Peptide binding and complex stability

    University dissertation from Department of Experimental Medical Science, Lund Univeristy

    Author : Elna Follin; Lund University.; Lunds universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The major histocompatibility class I (MHC-I) genes are highly polymorphic and the proteins that they encode play a crucial role in both the innate and the adaptive immune response. A MHC-I molecule consists of three parts, one polymorphic heavy chain, one invariant light chain, β2-microglobulin and a peptide of usually between 8-11 amino acids in length. READ MORE