Search for dissertations about: "MHC-I"

Showing result 26 - 28 of 28 swedish dissertations containing the word MHC-I.

  2. 26. Regulation of protein degradation by virus derived repeated amino acid sequences

    Author : Ainars Leonchiks; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epstein-Barr virus; glycine-alanine repeat; ubiquitin-proteasome pathway;

    Abstract : The ubiquitin-proteasome pathway plays a central role in the controlled degradation of short-lived and regulatory proteins important m a variety of cellular processes, including antigen presentation and combating viral infections. The presentation of antigenic peptides derived from ubiquitin-proteasome dependent degradation of vital proteins to MHC class I restricted cytotoxic T cells is a central component of antiviral responses. READ MORE

  4. 27. Regulation of T cell effector functions in the intestinal mucosa

    Author : Petra Holmkvist; Slemhinnans immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T cells; memory; intestine; cytokines; differentiation; IL-18; inflammation; antigen presentation;

    Abstract : T lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. READ MORE

  5. 28. Avian MHC: variation and selection in the wild

    Author : Helena Westerdahl; MEMEG; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; polymorphism; balancing selection; cDNA; avian malaria; great reed warbler; Djurekologi; bird; Animal ecology; immune defence; MHC class II; Major Histocompatibility Complex; MHC class I;

    Abstract : In vertebrates the Major Histocompatibility Complex (MHC) plays a central role in the specific immune defence against various pathogens. Compared with other coding genes the MHC genes exhibit an extremely high level of polymorphism that is maintained by balancing selection. READ MORE