Search for dissertations about: "MHc2TA"

Showing result 1 - 5 of 6 swedish dissertations containing the word MHc2TA.

  1. 1. Candidate Genes for Late Diabetic Complications

    University dissertation from Endocrinology

    Author : Eero Lindholm; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF; sekretion; LTA; Endocrinology; nephropathy; diabetes mellitus; retinopathy; neuropathy; genetic; UCP; diabetologi; AGER; MHc2TA; HLA-DQB1; Endokrinologi; secreting systems; diabetology;

    Abstract : Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The new WHO criteria for classification of diabetes takes into account also clinical stages dividing the diabetic patients into noninsulin requiring (NIR), insulin requiring for control (IRC) and insulin requiring for survival (IRS) subgroups. READ MORE

  2. 2. Immunogenetics of Parkinson's disease: Translational studies from rodents to humans

    University dissertation from Lund University: Faculty of Medicine

    Author : Itzia Jimenez; [2019]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; genetics; inflammation; α-synuclein; dopaminergic neurons; MHCII; Mhc2ta; Vra4; PFFs; microglia;

    Abstract : Parkinson's disease (PD) is a complex neurodegenerative disease, characterized by a progressive lossof dopaminergic neurons (DN) in the substantia nigra (SN) that innervate the striatum (ST) and pathologicalaccumulation of alpha-synuclein (αsyn) protein in aggregates called Lewy bodies (LB) and Lewy neurites(LN). As a complex disease, PD presents a genetically heterogeneous origin. READ MORE

  3. 3. Genetic regulation of neuroinflammation : A translational approach

    University dissertation from Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Author : Johan Öckinger; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), causing demyelination and axonal damage. As other complex diseases with an inflammatory or autoimmune component, MHC is a strong regulator of the disease and acts in concert with multiple nonMHC genes and environmental factors. READ MORE

  4. 4. Genetic regulation of nerve injury-induced neurodegeneration and inflammation

    University dissertation from Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Author : Maria Swanberg; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : p>Neurodegeneration and inflammation in the central nervous system (CNS) are hallmarks of several neurological disorders, including multiple sclerosis (MS), Alzheimer s disease and Parkinson s disease. The susceptibility of an individual to these conditions is complex, i.e. influenced by both genetic and environmental factors. READ MORE

  5. 5. Genetic dissection of models for neuroinflammation and neurodegeneration

    University dissertation from Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Author : Karin Harnesk; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Many central nervous system (CNS) diseases are characterized by inflammation and nerve cell loss, but the exact relationship between these phenomena is not known. The complex etiology of CNS disorders includes a genetic component. READ MORE