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Showing result 1 - 5 of 10 swedish dissertations matching the above criteria.
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1. Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function
Abstract : Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. READ MORE
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2. The Role of Melanocyte Lineage Genes in Melanoma
Abstract : Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. READ MORE
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3. Functional Studies of Genes Associated with Muscle Growth in Pigs and Hair Greying in Horses
Abstract : Domestic animals have become very different from their wild ancestors during domestication and animal breeding. This provides a good model to unravel the molecular mechanisms underlying phenotypic variation. In my thesis I have studied genes affecting two important traits, leanness in pigs and hair greying-associated melanoma in horses. READ MORE
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4. Maf transcription factors in beta cell function
Abstract : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. READ MORE
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5. Mapping trait genes in dogs : using the dog as a model organism
Abstract : Understanding the genetic background of a given phenotypic trait or disease has long intrigued scientists. Model organisms can be employed when it is not feasible or possible to find trait causality in human cohorts. READ MORE