Search for dissertations about: "MLV"

Showing result 1 - 5 of 6 swedish dissertations containing the word MLV.

  2. 1. Fusion activation in murine leukemia virus

    Author : Michael Wallin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MLV; retrovirus; virus entry; membrane fusion; disulphide isomerization;

    Abstract : This thesis describes the fusion activation in Murine leukaemia virus (MLV). During entry of retroviruses into uninfected cells, the viral and cellular membranes fuse. The fusion process is mediated by the viral envelope protein composed of three SU and TM heterodimers. READ MORE

  4. 2. Incorporation of cellular proteins into enveloped virus particles

    Author : Maria Hammarstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MLV; HIV-1; assembly; protein sorting; HfIV-6A; autoimmunity; MS;

    Abstract : This thesis work aimed to investigate the assembly and budding of enveloped virus particles with focus on the fate of cellular proteins, present in or near the plasma membrane (PM) where the budding occurs. It was previously shown that compact viruses, like alphaviruses, with a covering outer protein coat, did not contain any cellular proteins in the envelope. READ MORE

  5. 3. Activation of retrovirus spikes for membrane fusion

    Author : Robin Löving; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Retroviruses are enveloped viruses that use reverse transcriptase to convert their RNA genome into DNA which is integrated into the host DNA. They enter into the cell by a membrane fusion process. In this the viral membrane fuses with that of the cell so that the internal capsid of the virus with the genome can be released into the cell cytoplasm. READ MORE

  6. 4. Biophysical Studies of Apolipoprotein A-IM and a Partitioning study

    Author : Malin Suurkuusk; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Apolipoprotein A-IMilano; Apolipoprotein A-I; Lipoprotein; Lipid; Microcalorimetry; DCS; Denaturation; Guanidine Hydrochloride; Physics; Fysik; Chemistry; Kemi;

    Abstract : The major part of this thesis deals with the similarities and differences in some biophysical properties of apolipoprotein A-I (apo A-I) and the molecular variant apolipoprotein A-IMilano (apo A-IM), and the influence on lipid binding. A model compound partitioning study has also been performed. READ MORE

  7. 5. Human Endogenous Retroviruses: Studies on Transcriptional Activity and Genetic Variability

    Author : Patrik Medstrand; Malmö Klinisk virologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; virology; bacteriology; HERVs; Human endogenous retrovirus sequences; reverse transcriptase; Microbiology; differential RNA expression.; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : Endogenous retroviruses (ERVs) are believed to be remains of germ-line infections that have become fixed in the population. They are involved in pathophysiological conditions, in mechanisms leading to infection protection, and directly in the physiology of the organism by participating in the regulation of cellular gene expression. READ MORE