Search for dissertations about: "MMP-2 deficiency"

Found 3 swedish dissertations containing the words MMP-2 deficiency.

  2. 1. Choroidal neovascularization (CNV) : clinical and experimental aspects

    Author : Lennart Berglin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CNV; angiogenesis; age-related macular degeneration; AMD; aging; surgery; endothelial cells; VEGF; MMP; TIMP; MMP-2; immunohistochemistry; ECM; RPE; Bruch s membrane; wound healing; inflammation; macrophages; in-situ hybridization; mRNA; immature vessels; MMP-9; TIMP- 3; MMP-2 deficiency;

    Abstract : This work comprises different aspects of choroidal neovacularization (CNV); a leading cause of visual loss in the aged. It is an example of angiogenesis and a complication of age-related macular degeneration (AMD) The purpose was to study if patient age influences outcome of CNV surgery, to characterize the cellular content of CNV, to analyze the expression of vascular endothelial growth factor (VEGF) and various matrix metalloproteinases (MMP) and their inhibitors (TIMP) in CNV and to study if MMP-2 influences experimental CNV growth. READ MORE

  4. 2. Experimental studies of corneal neovascularisation

    Author : Branka Samolov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The cornea contains no vessels, which is a prerequisite for the maintenance of its transparency. Vessel ingrowth leads to opacification resulting in visual impairment, sometimes complete blindness. READ MORE

  5. 3. Matrix degrading proteases in the ovary : expression and function

    Author : Patrik Wahlberg; Tor Ny; Ilpo Huhtaniemi; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; ovary; ovulation; corpus luteum; plasminogen; PA; MMP; rat; mouse; Biokemi; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Abstract : Extracellular matrix degrading proteases from the plasminogen (plg) activator (PA) and the matrix metalloproteinase (MMP) systems have been implicated as important mediators of ovulation and corpus luteum (CL) formation and regression. The aim of this thesis was to investigate the expression and regulation of PAs and MMPs in the ovary and to examine their functional roles for CL formation and function. READ MORE