Search for dissertations about: "MMP"

Showing result 16 - 20 of 177 swedish dissertations containing the word MMP.

2. 16. Bowel irradiation: the effects on inflammation and matrix-metalloproteinases

   Author : ANDREA POLISTENA; Kirurgi; []
   Keywords : Radiotherapy; Inflammation; Colorectal Cancer; MMP-7; Matrilysin; Bacteria;

   Abstract : Background and aims: Radiotherapy is a valid treatment in cancer multimodal management but it is affected by severe systemic and local side effects. A murine small bowel model was used for the investigation of inflammatory features and apoptosis of local radiotherapy. READ MORE

4. 17. Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia

   Author : Anna Hogmalm; Göteborgs universitet; []
   Keywords : bronchopulmonary dysplasia; transgenic mice; inflammation; lung; interleukin-1; αvβ6 integrin; mmp-9; surfactant;

   Abstract : Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development of BPD. READ MORE

5. 18. Remodelling of extracellular matrix in rectal cancer and preoperative radiotherapy

   Author : Eva Angenete; Göteborgs universitet; []
   Keywords : radiotherapy; rectal cancer; extracellular matrix; MMP-2; PAI-1; uPA; Calprotectin; TGF-beta1;

   Abstract : BACKGROUND Preoperative radiotherapy reduces local recurrence due to rectal cancer, but increases postoperative morbidity. The aim of this thesis was to study the impact of radiotherapy on extracellular matrix (ECM) remodelling enzymes and growth factors after radiotherapy and also their possible use as surrogate markers for complications. READ MORE

6. 19. Systemic sclerosis : vascular, pulmonary and immunological aspects

   Author : Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

   Abstract : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. READ MORE

7. 20. Effect of Ischaemia-Reperfusion on Rabbit Kidney and Human Brain

   Author : Jagdish Shivlal Gondalia; Göteborgs universitet; []
   Keywords : Free radicals; ischaemia-reperfusion; cell bioenergetics; NMR; ESR; carotid artery stenosis; endarterectomy; allopurinol; acetylcysteine; MMP-1; ICAM-1; MCP-9; oxLDL;

   Abstract : Free radicals are produced in various organs at ischaemia-reperfusion. The final stage in radical damage is lipid peroxidation. We have demonstrated previously that a lipid-soluble antioxidant improves restoration of bioenergetics in rabbit kidneys after ischaemia, as reflected in 31P spectrometry. READ MORE